Search results for: Zoltán Giricz

Items from 1 to 20 out of 30 results

article

Selegiline reduces adiposity induced by high‐fat, high‐sucrose diet in male rats

Csilla Terézia Nagy, Gábor Koncsos, Zoltán V Varga, Tamás Baranyai, more

British Journal of Pharmacology > 175 > 18 > 3713 - 3726

Background and Purpose Incidence and severity of obesity are increasing worldwide, however, efficient and safe pharmacological treatments are not yet available. Certain MAO inhibitors reduce body weight, although their effects on metabolic parameters have not been investigated. Here, we have assessed effects of a widely used, selective MAO‐B inhibitor, selegiline, on metabolic parameters in a rat...

article

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Hans Erik Bøtker, Derek Hausenloy, Ioanna Andreadou, Salvatore Antonucci, more

Basic Research in Cardiology > 2018 > 113 > 5 > 1-73

article

Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria accounts for inaccurate quantification of proteins

G. Koncsos, Z. Varga, T. Baranyai, P. Ferdinandy, more

Journal of Molecular and Cellular Cardiology > 2018 > 120 > S > 5-6

article

Versatility of microglial bioenergetic machinery under starving conditions

Adam M. Nagy, Rebeka Fekete, Gergo Horvath, Gabor Koncsos, more

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2018 > 1859 > 3 > 201-214

Microglia are highly dynamic cells in the brain. Their functional diversity and phenotypic versatility brought microglial energy metabolism into the focus of research. Although it is known that microenvironmental cues shape microglial phenotype, their bioenergetic response to local nutrient availability remains unclear.In the present study effects of energy substrates on the oxidative and glycolytic...

article

Autophagosome formation is required for cardioprotection by chloramphenicol

Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Csilla Terézia Nagy, more

Life Sciences > 2017 > 186 > C > 11-16

Chloramphenicol (CAP), a broad spectrum antibiotic, was shown to protect the heart against ischemia/reperfusion (I/R) injury. CAP also induces autophagy, however, it is not known whether CAP-induced cardioprotection is mediated by autophagy. Therefore, here we aimed to assess whether activation of autophagy is required for the infarct size limiting effect of CAP and to identify which component of...

article

Erratum to: Hypercholesterolemia downregulates autophagy in the rat heart

Zoltán Giricz, Gábor Koncsos, Tomáš Rajtík, Zoltán V. Varga, more

Lipids in Health and Disease > 2017 > 16 > 1 > 1-1

The online version of the original article can be found under doi: 10.1186/s12944-017-0455-0

article

Effect of hypercholesterolaemia on myocardial function, ischaemia–reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

Ioanna Andreadou, Efstathios K Iliodromitis, Antigone Lazou, Anikó Görbe, more

British Journal of Pharmacology > 174 > 12 > 1555 - 1569

Hypercholesterolaemia is considered to be a principle risk factor for cardiovascular disease, having direct negative effects on the myocardium itself, in addition to the development of atherosclerosis. Since hypercholesterolaemia affects the global cardiac gene expression profile, among many other factors, it results in increased myocardial oxidative stress, mitochondrial dysfunction and inflammation...

article

In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature

Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, more

Journal of Translational Medicine > 2017 > 15 > 1 > 1-13

Background Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies and clinical trials utilize necrotic tissue referred to the area at risk (AAR) by magnetic resonance imaging (MRI). However, determination of AAR by MRI‚ may not be accurate, since...

article

Hypercholesterolemia downregulates autophagy in the rat heart

Zoltán Giricz, Gábor Koncsos, Tomáš Rajtík, Zoltán V. Varga, more

Lipids in Health and Disease > 2017 > 16 > 1 > 1-8

Background We have previously shown that efficiency of ischemic conditioning is diminished in hypercholesterolemia and that autophagy is necessary for cardioprotection. However, it is unknown whether isolated hypercholesterolemia disturbs autophagy or the mammalian target of rapamycin (mTOR) pathways. Therefore, we investigated whether isolated hypercholesterolemia modulates cardiac autophagy-related...

article

Protection of neonatal rat cardiac myocytes against radiation-induced damage with agonists of growth hormone-releasing hormone

Laura Kiscsatári, Zoltán Varga, Andrew V. Schally, Renáta Gáspár, more

Pharmacological Research > 2016 > 111 > C > 859-866

Despite the great clinical significance of radiation-induced cardiac damage, experimental investigation of its mechanisms is an unmet need in medicine. Beneficial effects of growth hormone-releasing hormone (GHRH) agonists in regeneration of the heart have been demonstrated. The aim of this study was the evaluation of the potential of modern GHRH agonistic analogs in prevention of radiation damage...

article

Data on necrotic and apoptotic cell death in acute myocardial ischemia/reperfusion injury: the effects of CaMKII and angiotensin AT1 receptor inhibition

Tomas Rajtik, Slavka Carnicka, Adrian Szobi, Zoltan Giricz, more

Data in Brief > 2016 > 7 > C > 730-734

Content of particular proteins indicating cellular injury due to apoptosis and necrosis has been investigated in ischemic/reperfused (IR) hearts and ischemic/reperfused hearts treated with CaMKII inhibitor and/or AT₁ receptor inhibitor. This data article provides information in support of the original research article “Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury:...

article

Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury: A role of angiotensin AT1 receptor-NOX2 signaling axis

Tomas Rajtik, Slavka Carnicka, Adrian Szobi, Zoltan Giricz, more

European Journal of Pharmacology > 2016 > 771 > C > 114-122

During ischemia/reperfusion (IR), increased activation of angiotensin AT₁ receptors recruits NADPH oxidase 2 (NOX2) which contributes to oxidative stress. It is unknown whether this stimulus can induce oxidative activation of Ca²⁺/calmodulin-dependent protein kinase IIδ (CaMKIIδ) leading into the aggravation of cardiac function and whether these effects can be prevented by angiotensin AT₁ receptors...

article

A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology

Rosalinda Madonna, Christian Cadeddu, Martino Deidda, Zoltán Giricz, more

International Journal of Cardiology > 2015 > 191 > Complete > 203-210

Ischemic heart disease remains the leading cause of death worldwide. Ischemic pre-, post-, and remote conditionings trigger endogenous cardioprotection that renders the heart resistant to ischemic–reperfusion injury (IRI). Mimicking endogenous cardioprotection by modulating genes involved in cardioprotective signal transduction provides an opportunity to reproduce endogenous cardioprotection with...

article

Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

Zoltán V. Varga, Zoltán Giricz, Lucas Liaudet, György Haskó, more

BBA - Molecular Basis of Disease > 2015 > 1852 > 2 > 232-242

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic cardiovascular dysfunction also underscores the development of diabetic retinopathy, nephropathy and neuropathy. Despite the broad availability of antidiabetic therapy, glycemic control still remains a major challenge in the management of diabetic patients. Hyperglycemia triggers formation of advanced glycosylation...

article

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning

Tamás Baranyai, Csilla Terézia Nagy, Gábor Koncsos, Zsófia Onódi, more

Cardiovascular Diabetology > 2015 > 14 > 1 > 1-10

Background Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been studied...

article

Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop

Jack M. J. Pickard, Hans Erik Bøtker, Gabriele Crimi, Brian Davidson, more

Basic Research in Cardiology > 2015 > 110 > 1 > 1-13

In 1993, Przyklenk and colleagues made the intriguing experimental observation that ‘brief ischemia in one vascular bed also protects remote, virgin myocardium from subsequent sustained coronary artery occlusion’ and that this effect ‘…. may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemia/reperfusion’. This seminal study laid the foundation for...

article

On-Line Visualization of Ischemic Burden During Repetitive Ischemia/Reperfusion

Noemi Pavo, Maximilian Y. Emmert, Zoltán Giricz, Zoltán V. Varga, more

JACC: Cardiovascular Imaging > 2014 > 7 > 9 > 956-958

article

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Zoltán Giricz, Zoltán V. Varga, Tamás Baranyai, Péter Sipos, more

Journal of Molecular and Cellular Cardiology > 2014 > 68 > Complete > 75-78

Remote ischemic preconditioning (RIPC) of the heart is exerted by brief ischemic insults affected on a remote organ or a remote area of the heart before a sustained cardiac ischemia. To date, little is known about the inter-organ transfer mechanisms of cardioprotection by RIPC. Exosomes and microvesicles/microparticles are vesicles of 30–100nm and 100–1000nm in diameter, respectively (collectively...

article

Atypical heat shock response and acquisition of thermotolerance in P388D1 cells

Deepu Oommen, Zoltan Giricz, Usha K. Srinivas, Afshin Samali

Biochemical and Biophysical Research Communications > 2013 > 430 > 1 > 236-240

Reports of atypical heat shock response in some tumour cell lines emphasize the possibilities of alternate stress response mechanisms. We demonstrate here that P388D1, a mouse macrophage tumour cell line, failed to induce heat shock proteins (HSPs) in response to either heat stress (42°C, 1h) or to heavy metal stress induced by arsenic trioxide (5–20μM). Heat shock transcriptional factor 1 (HSF1)...

article

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress

Sanjeev Gupta, Zoltan Giricz, Alessandro Natoni, Neysan Donnelly, more

FEBS Letters > 2012 > 586 > 22 > 4023-4030

PKR-like ER kinase (PERK) deficient mouse embryonic fibroblasts (MEFs) are hypersensitive to ER stress-induced apoptosis. However, the molecular determinants of increased sensitivity of PERK^−/− MEFs are not clearly understood. Here we show that induction of several Unfolded Protein Response (UPR) target genes is attenuated in PERK^−/− MEFs. We also report elevated expression of the BH3-only protein,...

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Search results for: Zoltán Giricz

Selegiline reduces adiposity induced by high‐fat, high‐sucrose diet in male rats

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria accounts for inaccurate quantification of proteins

Versatility of microglial bioenergetic machinery under starving conditions

Autophagosome formation is required for cardioprotection by chloramphenicol

Erratum to: Hypercholesterolemia downregulates autophagy in the rat heart

Effect of hypercholesterolaemia on myocardial function, ischaemia–reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature

Hypercholesterolemia downregulates autophagy in the rat heart

Protection of neonatal rat cardiac myocytes against radiation-induced damage with agonists of growth hormone-releasing hormone

Data on necrotic and apoptotic cell death in acute myocardial ischemia/reperfusion injury: the effects of CaMKII and angiotensin AT1 receptor inhibition

Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury: A role of angiotensin AT1 receptor-NOX2 signaling axis

A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology

Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning

Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop

On-Line Visualization of Ischemic Burden During Repetitive Ischemia/Reperfusion

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Atypical heat shock response and acquisition of thermotolerance in P388D1 cells

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress

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