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Mesenchymal stem cell (MSC) therapy is a promising prospect for the treatment of Alzheimer’s disease (AD); however, the underlying mechanisms by which MSCs mediate positive effects are still unclear. We speculated that MSCs mediate microglial autophagy and enhance the clearance of Aβ. To test this hypothesis, we cultured BV2 microglial cells with umbilical cord mesenchymal stem cells conditioned medium...
We have previously reported the successful development of a targeted genetic method for the creation of temperature-sensitive vaccinia virus mutants [D. E. Hassett and R. C. Condit (1994)Proc. Natl. Acad. Sci. USA91, 4554–4558]. This method has now been applied to the large subunit of the multifunctional vaccinia virus capping enzyme, encoded by gene D1R. Ten clustered charge-to-alanine mutations...
The underpotential deposition (upd) of Pb and Cd on Ag(111) and Au(111) single crystals grown on freshly cleaved mica has been examined in propylene carbonate (PC), water, tetrahydrofuran (THF), and dimethoxyethane (DME) by cyclic voltammetric techniques. Insight into the cleanliness of the single crystal metal electrode/non-aqueous electrolyte interfaces was gained from a comparison of the potential...
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