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Background: The β1-adrenergic receptor (β1-AR) is central to regulation of myocardial contractility. In the failing heart, the β1-AR is chronically over-stimulated due to high concentrations of norepinephrine. Therefore, we wished to examine the effect of constitutive β1-AR over-expression in myocardial tissues.Methods: The human β1-AR was overexpressed in transgenic (TG) mice, in a cardiac-specific...
The effects of different opioid substances on isoproterenol and forskolin-stimulated cyclic AMP (cAMP) intracellular accumulation, and on the binding of 125 I-pindodol (IPIN) to β2-adrenoceptors were studied in human mononuclear leukocytes (MNL). The opioids used were α-endorphin, β-endorphin, τ-endorphin, DAGO (a μ receptor agonist), dermenkephalin (a δ receptor agonist and morphine...
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