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The total number of circulating CD4+ and CD8+ T-cells undergoing clonal expansions following SIV mac251 infection was determined using a T-cell receptor Vβ chain (TRBV) third complementarity-determining region (CDR3) DNA heteroduplex tracking assay (HTA). This assay measures the number of newly expanding T-cell clones but not their antigenic specificity. Fewer expanding...
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