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Fas/Fas ligand system triggers apoptosis in many cell types. Bcl‐XL overexpresion antagonizes Fas/Fas ligand‐mediated cell death. The mechanism by which Bcl-XL influences Fas‐mediated cell death is unclear. We have found that microtubule‐damaging drugs (e.g. Paclitaxel) induce apoptosis in a Fas/FasL‐dependent manner. Inhibition of Fas/FasL pathway by anti‐FasL antibody, mutant Fas or a dominant negative...
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