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Human adenovirus (Ad) types 2, 3 and 12 are known to interact with cell surface integrins α v β 3 and α v β 5 through an RGD motif carried by the penton base. This interaction is thought to augment virus entry after initial contact between the fiber and specific receptor(s). Ad40 and Ad41 are the only members of the human subgroup F adenoviruses. The penton base protein...
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