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Tetrahydrobiopterin (BH 4 ) is required for NO synthesis and inhibition of superoxide release from endothelial NO synthase. Clinical trials using BH 4 to treat endothelial dysfunction have produced mixed results. Poor outcomes may be explained by the rapid systemic and cellular oxidation of BH 4 . One of the oxidation products of BH 4 , 7,8-dihydrobiopterin (7,8-BH...
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