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Fat occupies a significant portion of bone cavity however its function is largely unknown. Marrow fat expands during aging and in conditions which affect energy metabolism, indicating that fat in bone is under similar regulatory mechanisms as other fat depots. On the other hand, its location may determine specific functions in the maintenance of the environment for bone remodeling and hematopoiesis...
IL-1β is known to be a potent stimulator of bone resorption in vitro and in vivo and to stimulate IL-6 and PGE 2 production by osteoblastic cells. IL-6 is a multifunctional cytokine which has diverse effects on bone metabolism. Prostaglandins may play a role as local mediators in bone and their synthesis by osteoblasts is regulated by both systemic hormones and cytokines. The effect of IL-1β...
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