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Pinus massoniana bark extract (PMBE) is a natural product developed in China, with flavonoids, especially proanthocyanidins, as its main components. Flavonoids are shown to inhibit the abnormally high expression of cathepsin B (CatB) in some tumour cells. CatB is normally located in lysosomes and plays a role in the autophagy process. However, if the cells turn malignant, CatB may secrete and take...
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