ObjectiveTo understand the roles of microRNAs (miRNAs) in proliferative lupus nephritis (LN).
MethodsA high‐throughput analysis of the miRNA pattern of the kidneys of LN patients and controls was performed by molecular digital detection. Urinary miRNAs were measured by quantitative reverse transcription–polymerase chain reaction (qRT‐PCR). Target gene expression in human mesangial cells was evaluated...
Interferon regulatory factor 1 (IRF‐1) mediates both induction of interferons (IFNs) and responses to type I IFNs. It has been implicated as a critical mediator of inflammation in murine lupus models. In a previous study of chromatin modifications in monocytes from patients with systemic lupus erythematosus (SLE), IRF‐1 was implicated as being associated with increased histone acetylation...
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