Search results for: Martin Kerschensteiner

Items from 1 to 14 out of 14 results

article

TSPO imaging using the novel PET ligand [¹⁸F]GE-180: quantification approaches in patients with multiple sclerosis

Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, more

EJNMMI Research > 2017 > 7 > 1 > 1-9

Background PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [¹⁸F]GE-180 in patients with relapsing remitting multiple sclerosis (RRMS) and an approach for semi-quantitative assessment of this disease in clinical routine.Seventeen dynamic...

article

Antiglutamatergic therapy for multiple sclerosis?

Reinhard Hohlfeld, Martin Kerschensteiner

The Lancet Neurology > 2016 > 15 > 10 > 1003-1004

article

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, more

Cell Reports > 2016 > 16 > 2 > 314-322

Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down into vesicular structures at the innermost region of the myelin sheath. We demonstrated that myelin...

chapter

Neuro-Immune Crosstalk in CNS Diseases

Martin Kerschensteiner, Edgar Meinl, Reinhard Hohlfeld

Results and Problems in Cell Differentiation > Molecular Basis of Multiple Sclerosis > 197-216

Immune cells infiltrate the central nervous system (CNS) in many neurological diseases, with a primary or secondary inflammatory component. In the CNS, immune cells employ shared mediators to promote crosstalk with neuronal cells. The net effect of this neuro-immune crosstalk critically depends on the context of the interaction. It has long been established that inflammatory reactions in the CNS can...

article

Die Verformungsberechnung der Lahntalbrücke Limburg

Stephan Sonnabend, Stefan Franz, Christina Steinbrück, Martin Kerschensteiner

Beton‐ und Stahlbetonbau > 111 > 2 > 77 - 89

Die Neue Lahntalbrücke bei Limburg ist ein semi‐integrales Spannbetonbauwerk, das aus einem Realisierungswettbewerb hervorgegangen ist. Es zeichnet sich durch seine schlanke, ansprechende Gestaltung aus. Das Bauwerk wird im Freivorbau hergestellt. Nachfolgend werden die Besonderheiten für die Verformungsberechnung der Lahntalbrücke vorgestellt. Dabei wird erläutert, welche Überlegungen zu der letztlich...

article

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

Bettina Schreiner, Elisa Romanelli, Pawel Liberski, Barbara Ingold-Heppner, more

Cell Reports > 2015 > 12 > 9 > 1377-1384

Although the importance of reactive astrocytes during CNS pathology is well established, the function of astroglia in adult CNS homeostasis is less well understood. With the use of conditional, astrocyte-restricted protein synthesis termination, we found that selective paralysis of GFAP⁺ astrocytes in vivo led to rapid neuronal cell loss and severe motor deficits. This occurred while structural astroglial...

article

Role of the innate and adaptive immune responses in the course of multiple sclerosis

Bernhard Hemmer, Martin Kerschensteiner, Thomas Korn

The Lancet Neurology > 2015 > 14 > 4 > 406-419

Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most patients. The early phase is characterised by relapses and the later phase by progressive disability. Results from immunological, genetic, and histopathological studies and treatment trials have shown that the immune system plays a key part in the disease course. Findings from animal models and immunological...

article

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

Catherine Diamante Sorbara, Naomi Elizabeth Wagner, Anne Ladwig, Ivana Nikić, more

Neuron > 2014 > 84 > 6 > 1183-1190

Impaired axonal transport can contribute to axon degeneration and has been described in many neurodegenerative diseases. Multiple sclerosis (MS) is a common neuroinflammatory disease, which is characterized by progressive axon degeneration—whether, when, and how axonal transport is affected in this condition is unknown. Here we used in vivo two-photon imaging to directly assay transport of organelles...

article

Plasticity of mononuclear phagocytes in an animal model of Multiple Sclerosis

Delphine Theodorou, Giuseppe Locatelli, Athanasios Dagkalis, Martin Kerschensteiner

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 176

article

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

Jonathan Gilley, Anjan Seereeram, Kunie Ando, Suzanne Mosely, more

Neurobiology of Aging > 2012 > 33 > 3 > 621.e1-621.e15

Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates. Toxic effects of aggregated tau and/or dysfunction of soluble tau could both contribute to neural defects in these neurodegenerative diseases. We have generated a novel knockin mouse model of an inherited tauopathy, frontotemporal dementia with parkinsonism...

article

Strategies for axonal repair in central nervous system diseases

Martin Kerschensteiner

Journal of Neurology > 2007 > 254 > 1 > I29-I32

Significant functional recovery after spinal cord injury can be observed in rodents, in spite of the presence of extensive irreversible structural damage. One potential mechanism for functional regeneration of the corticospinal tract may involve the formation of new spinal circuits remote from the lesion that allow the lesion site to be by-passed and contact re-established with the original targets...

article

Behavioral testing strategies in a localized animal model of multiple sclerosis

Bigna S. Buddeberg, Martin Kerschensteiner, Doron Merkler, Christine Stadelmann, more

Journal of Neuroimmunology > 2004 > 153 > 1-2 > 158-170

To assess neurological impairments quantitatively in an animal model of multiple sclerosis (MS), we have used a targeted model of experimental autoimmune encephalomyelitis (EAE), which leads to the formation of anatomically defined lesions in the spinal cord. Deficits in the hindlimb locomotion are therefore well defined and highly reproducible, in contrast to the situation in generalized EAE with...

article

Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis

Martin Kerschensteiner, Christine Stadelmann, Bigna S. Buddeberg, Doron Merkler, more

The American Journal of Pathology > 2004 > 164 > 4 > 1455-1469

In multiple sclerosis (MS) the structural damage to axons determines the persistent clinical deficit patients acquire during the course of the disease. It is therefore important to test therapeutic strategies that can prevent or reverse this structural damage. The conventional animal model of MS, experimental autoimmune encephalomyelitis (EAE), typically shows disseminated inflammation in the central...

article

The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis

Reinhard Hohlfeld, Martin Kerschensteiner, Christine Stadelmann, Hans Lassmann, more

Journal of Neuroimmunology > 2000 > 107 > 2 > 161-166

Autoreactive T cells are a component of the normal immune system. It has been proposed that some of these autoreactive T cells even have a protective function. Recent studies support this notion by demonstrating that (a) myelin basic-protein (MBP-) specific T cells show neuroprotective effects in vivo, and (b) activated antigen-specific human T cells and other immune cells produce bioactive brain-derived...

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