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The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of theReoviridae , was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme pyrophosphate biding site. Replication of rotavirus in MA104 cells using different u.o.i. was inhibited by PFA in a concentration dependent manner, due to the inhibition of both plus-...
Based on the antiviral effect of interferon on rotavirus replication the inhibitory effect of 2 ,5 -oligoadenylates on MRNA and double-stranded RNA synthesis was studied using an in vitro assay. The chemically synthesized oligonucleotides were used to determine several characteristics of the inhibitory effect, such as chain length, presence of phosphate residues at the 5 -end, and the 2 ,5 -phosphodiester...
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