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BACKGROUNDLow levels of selenium have been associated with increased risk of prostate cancer (PCa). Selenoprotein P is the most abundant selenoprotein in serum and delivers ten selenocysteine residues to tissues. Variation in the selenoprotein P gene (SEPP1) may influence PCa development or modify the effects of selenium. We examined the association of SEPP1 single nucleotide polymorphisms (SNPs)...
BACKGROUNDα‐Methylacyl‐CoA racemase (AMACR) is an enzyme that serves as a diagnostic biomarker of prostate cancer in clinical practice. Recent studies suggest that low AMACR expression is associated with biochemical recurrence and the development of fatal disease.
METHODSWe conducted a prospective cohort study among 920 men aged 47–84 years, who were diagnosed with prostate cancer in the Physicians'...
BACKGROUNDCommon genetic variants in the Toll‐like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer.
METHODSIn a large nested case–control study of prostate cancer in the Physicians' Health Study (1982–2004), 10 single nucleotide polymorphisms (SNPs) were selected and genotyped to capture common variation within the TLR4 gene...
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