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Background
The use of lithium during breast‐feeding has not been comprehensively investigated in humans due to concerns about lithium toxicity.
Procedure
We analyzed lithium in the kidneys of nursed pups of lithium medicated mothers, using analytical spectroscopy in a novel rat model. The mothers were healthy rats administered lithium via gavage (1000 mg/day Li2CO3 per 50 kg body weight).
Results...
In this paper a new VRP variant the Multiple Trip Vehicle Routing Problem with Backhauls (MT-VRPB) is investigated. The classical MT-VRP model is extended by including the backhauling aspect. An ILP formulation of the MT-VRPB is first presented and CPLEX results for small and medium size instances are reported. For large instances of the MT-VRPB a Two-Level VNS algorithm is developed. To gain a continuous...
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