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Background. Obesity and diabetes are major risk factors for the development of cholesterol gallstones, and the majority of obese people have leptin-resistant obesity. Previous studies from our laboratory have demonstrated that both leptin-deficient (Lep ob ) and leptin-resistant (Lep db ) obese diabetic mice have decreased in vitro gallbladder motility. We have also shown...
Background. Obesity is associated with multiple comorbidities, altered leptin metabolism, and increased intestinal absorption of nutrients. We have recently demonstrated that leptin-deficient (Lep ob ) obese mice have increased ileal sucrase activity resulting in greater absorption of carbohydrate than lean controls. We have also demonstrated altered in vitro jejunal responses to cholecystokinin...
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