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L’expression des antigènes LE1 et LE2 dépend des fucosyltransférases FUT2 (SE) et FUT3 (LE), en compétition pour le même substrat dans les cellules sécrétrices. Les actions de FUT2, puis de FUT3 forment LE2. Si FUT2 est altérée, alors FUT3 peut agir en premier, rendant l’ajout de fucose supplémentaire impossible et LE1 est formé. Le phénotype LE:1,2 est possible si l’activité de FUT2 est réduite mais...
Background and ObjectiveThe locus specifying the MNS blood group system is composed of three highly homologous genes, glycophorin A (GYPA), B (GYPB) and E (GYPE). While more than 20 hybrid genes between GYPA and GYPB have been identified, no hybrid genes between GYPB and GYPE have been reported so far. We serendipitously identified GYPB‐E‐B hybrid genes by studying three individuals whose rare S−s−...
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