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The IEEE 802.3az standard, known as Energy Efficient Ethernet (EEE), is one of recent efforts to improve energy efficiency in communications. However, EEE may not achieve good energy efficiency on some traffic patterns. Coalescing techniques were proposed to solve this problem, but their implementations typically employ a simple polity and need further optimization. Adaptive interrupt coalescing (AIC)...
The RNA exosome is a 3′–5′ ribonuclease complex that is composed of nine core subunits and an essential catalytic subunit, Rrp44. Two distinct conformations of Rrp44 were revealed in previous structural studies, suggesting that Rrp44 may change its conformation to exert its function. In the channeling conformation, (Rrp44ch), RNA accesses the active site after traversing the central channel of the...
Mycobacterium tuberculosis possesses a proteasome system that is required for the microbe to resist elimination by the host immune system. Despite the importance of the proteasome in the pathogenesis of tuberculosis, the molecular mechanisms by which proteasome activity is controlled remain largely unknown. Here, we demonstrate that the α-subunit (PrcA) of the M. tuberculosis proteasome is phosphorylated...
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