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The GTP-dependent calcium release from rat liver microsomes is known to be promoted in the presence of colloids like polyethyleneglycol (PEG), polyvinylpyrrolidine, or albumin. Dawson et al. [(1987) Biochem. J. 244, 87-92] using the 'fusogen' PEG have concluded that both GTP-induced calcium efflux and the enhancement of InsP 3 -promoted calcium release in the presence of GTP could be attributed...
A heterologous and homologous desensitization of the glycogenolytic response against 3',5'-cAMP independent hormones in isolated hepatocytes has been reported [Biochem. J. (1981) 200, 509-514]. We re-examined this phenomenon in isolated perfused rat livers, isolated hepatocytes during stationary incubation and in isolated perifused hepatocytes. The release of glucose and the activation of glycogen...
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