Search results for: Agata Kosmaczewska

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CTLA-4 affects expression of key cell cycle regulators of G0/G1 phase in neoplastic lymphocytes from patients with chronic lymphocytic leukaemia

Lidia Ciszak, Irena Frydecka, Dariusz Wolowiec, Aleksandra Szteblich, more

Clinical and Experimental Medicine > 2016 > 16 > 3 > 317-332

Previously, we showed that cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is overexpressed in chronic lymphocytic leukaemia (CLL) and its expression is correlated with the expression of the major regulators of G1 phase progression: cyclins D2 and D3, and cyclin-dependent kinase inhibitory protein 1 (p27^KIP1). In the present study, we blocked CTLA-4 on the surface of...

article

Patients with chronic lymphocytic leukaemia (CLL) differ in the pattern of CTLA-4 expression on CLL cells: the possible implications for immunotherapy with CTLA-4 blocking antibody

Lidia Ciszak, Irena Frydecka, Dariusz Wolowiec, Aleksandra Szteblich, more

Tumor Biology > 2016 > 37 > 3 > 4143-4157

Recently, systemic administration of a human monoclonal antibody directed against cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on circulating T cells in patients with chronic lymphocytic leukaemia (CLL) has been considered. Also, CLL cells have been shown to express CTLA-4, increased levels of which in the leukaemic compartment are a predictor of good clinical outcome. Since both...

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Pretransplant donor and recipient CTLA-4 mRNA and protein levels as a prognostic marker for aGvHD in allogeneic hematopoietic stem cell transplantation

Lidia Karabon, Miroslaw Markiewicz, Agata Kosmaczewska, Anna Partyka, more

Immunology Letters > 2015 > 165 > 1 > 52-59

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory T cells’ receptor essential for maintaining T cell homeostasis and immunotolerance. The role of the co-stimulatory pathway in development of aGvHD has been studied mostly in animal models. To the best of our knowledge, there are no published data on the role of CTLA-4 in pathogenesis of aGvHD after hematopoietic stem cell transplantation (HSCT)...

article

Exogenous IL-2 Controls the Balance in Th1, Th17, and Treg Cell Distribution in Patients with Progressive Rheumatoid Arthritis Treated with TNF-Alpha Inhibitors

Agata Kosmaczewska, Lidia Ciszak, Jerzy Swierkot, Aleksandra Szteblich, more

Inflammation > 2015 > 38 > 2 > 765-774

Interleukin-2 (IL-2) has been suggested to control Treg/Th17 balance. Recently, we reported a relationship of rheumatoid arthritis (RA) activity/progression with irreversible systemic Treg and Th1 defects including serum IL-2 shortage. Herein, we explore the role of in vitro stimulation with rIL-2 in the observed immune alterations reversal. Patients with stable or progressive RA were assigned to...

article

Alterations in Both the Activatory and Inhibitory Potential of Peripheral Blood CD4+ T Cells in Rheumatoid Arthritis Patients Correlate with Disease Progression

Agata Kosmaczewska, Lidia Ciszak, Jerzy Swierkot, Aleksandra Szteblich, more

Pathology & Oncology Research > 2014 > 20 > 2 > 235-243

The chronic nature of rheumatoid arthritis (RA) suggests immune dysfunction, including persistent systemic activation. Therefore, we evaluated the activatory and inhibitory potential as well as proliferative activity of peripheral blood (PB) CD4+ T cells from RA patients in different stages of the disease and after different therapeutic interventions. We found that CD4+ T cells from RA patients were...

article

Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

Agata Kosmaczewska, Jerzy Swierkot, Lidia Ciszak, Aleksandra Szteblich, more

Rheumatology International > 2014 > 34 > 2 > 243-253

Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been recently attributed to Th1 responses. The aim of the study was to estimate the extent...

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Dysregulated Expression of Both the Costimulatory CD28 and Inhibitory CTLA-4 Molecules in PB T Cells of Advanced Cervical Cancer Patients Suggests Systemic Immunosuppression Related to Disease Progression

Agata Kosmaczewska, Dorota Bocko, Lidia Ciszak, Iwona Wlodarska-Polinska, more

Pathology & Oncology Research > 2012 > 18 > 2 > 479-489

Cervical cancer (CC) occurs more frequently in women who are immunosuppressed, suggesting that both local and systemic immune abnormalities may be involved in the evolution of the disease. Costimulatory CD28 and inhibitory CTLA-4 molecules expressed in T cells play a key role in the balanced immune responses. There has been demonstrated a relation between CD28, CTLA-4, and IFN genes in susceptibility...

article

Zeta chain expression in T and NK cells in peripheral blood of children with nephrotic syndrome

Kinga Musiał, Lidia Ciszak, Agata Kosmaczewska, Aleksandra Szteblich, more

Pediatric Nephrology > 2010 > 25 > 1 > 119-127

The idiopathic nephrotic syndrome (INS) has been related to cellular immune disturbances. The zeta (ζ) chain, a component of the T-cell receptor/CD3 (TCR) complex and CD16 heterodimer in NK cells, plays a crucial role in T and NK cell activation and proliferation. The aim of our study was to examine zeta chain expression in CD4+, CD8+ T lymphocytes and NK cells in the peripheral blood of children...

article

The significance of Treg cells in defective tumor immunity

Agata Kosmaczewska, Lidia Ciszak, Stanisław Potoczek, Irena Frydecka

Archivum Immunologiae et Therapiae Experimentalis > 2008 > 56 > 3 > 181-191

Regulatory T cells (Treg) enriched in FoxP3⁺, glucocorticoid-induced TNF receptor⁺, and cytotoxic T-lymphocyte-associated antigen-4⁺ exert a potential to suppress effector T cells in the periphery. These cells exist in markedly higher proportions within tumor-infiltrating lymphocytes, peripheral blood lymphocytes, and/or regional lymph node lymphocytes of patients with cancer and their frequencies...

article

Alterations in the expression of signal-transducing CD3ζ chain in T cells from patients with chronic inflammatory/autoimmune diseases

Lidia Ciszak, Edyta Pawlak, Agata Kosmaczewska, Stanisław Potoczek, more

Archivum Immunologiae et Therapiae Experimentalis > 2007 > 55 > 6 > 373-386

The CD3ζ chain, a component of the T cell receptor (TCR)/CD3 complex, is considered to be a limiting factor in the assembly and transport of the TCR/CD3 complex to the cell surface and is crucial to receptor signaling function. Recent studies have demonstrated altered expression and function of this signal transduction molecule in T and natural killer cells in patients with chronic inflammatory/autoimmune...

article

CD40L, CD28, and CTLA-4 expression on CD4+ T cells in kidney graft recipients: A relationship with post-transplantation clinical course

Agata Kosmaczewska, Maria Magott-Procelewska, Irena Frydecka, Lidia Ciszak, more

Transplant Immunology > 2006 > 16 > 1 > 32-40

Experimental studies have demonstrated that the intensity of alloreactivity against a transplanted organ results from an interaction of positive (CD40/CD40L and B.7/CD28) and inhibitory (B.7/CTLA-4) signals between antigen-presenting cells (APCs) and T lymphocytes.We examined the CD40L, CD28, and both surface (s) and intracellular (i) CTLA-4 expressions on freshly drawn and anti-CD3+rIL-2-stimulated...

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