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The purpose of this study was to examine the renal effects of a V2 receptor arginine vasopressin (AVP) antagonist in heart failure.Arginine vasopressin has been implicated in the renal water retention and dilutional hyponatremia associated with chronic heart failure.We examined the effects of the oral, non-peptide, selective V2 receptor antagonist lixivaptan in 42 diuretic-requiring patients with...
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