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To investigate the role of integrin and G protein pathways in the mechanotransduction process within MCCs and explore the possible crosstalk between the two traditional signal pathways, in vitro-cultured rabbit MCCs were treated with pressure. The mRNA level of α5β1 integrin was determined by in situ hybridization and the distributions of vinculin, Gαq/11 protein, F-actin and intracellular calcium...
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