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5-Chlorolevulinic acid (5-CLA) is an α-chloroketone analog of the tetrapyrrole precursor 5-aminolevulinate (ALA). As such it serves as an excellent probe of the mechanisms of enzymes which form or utilize ALA. The enzyme porphobilinogen synthase (PBGS) catalyzes the condensation of two molecules of ALA to form the monopyrrole porphobilinogen. In principle, 5-CLA could bind at either or both of the...