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The role of the B7 family molecules in the regulation of the immune response is well documented. A large body of experimental evidence indicates that costimulatory molecules such as B7-1, B7-2, B7-DC, B7-H1, B7-H2, B7-H3 and B7-H4 are critical for initiation, maintenance and down-regulation of the immune response. However the immunological function of butyrophilin (BTN)-like molecules, which are a...
Four independent phage clones containing the fragments of cone-specific cGMP phosphodiesterase (PDE) α subunit (PDEα ) cDNA were isolated from the human cDNA library. The screening of the genomic library resulted in isolation of four independent phage clones with the fragments of human cone PDEα gene including 5 -flanking region and exons ranged from 1 to 14 (overall 32 kilobases). Structural...
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