Search results for: Panagiotis S. Kabouridis

Items from 1 to 9 out of 9 results

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Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

Panagiotis S. Kabouridis, Reena Lasrado, Sarah McCallum, Song Hui Chng, more

Neuron > 2015 > 85 > 2 > 289-295

The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under...

article

Distinct localization of T cell Agrin during antigen presentation – evidence for the expression of Agrin receptor(s) in antigen‐presenting cells

Panagiotis S. Kabouridis, Tatiana A. Pimentel, Vincenzo Brancaleone, Fulvio D’Acquisto, more

The FEBS Journal > 279 > 13 > 2368 - 2380

Agrin is over‐expressed by activated and autoimmune T cells, and synergizes with the T cell receptor (TCR) to augment cell activation. In the present study, we show that Agrin accumulates to distinct areas of the plasma membrane and that cell activation causes its redistribution. During antigen presentation, Agrin primarily accumulates to the periphery of the mature immunological synapse, mostly in...

article

Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells

Apostolos Koutsokeras, Panagiotis S. Kabouridis

BBA - General Subjects > 2009 > 1790 > 2 > 147-153

Intracellular signaling can be regulated by the exogenous addition of physiological protein inhibitors coupled to the TAT protein transduction domain. Thus far experiments have been performed with purified inhibitors added exogenously to cells in vitro or administered in vivo. Production of secretable TAT-fusion proteins by engineered mammalian cells, their uptake, and route of entry has not been...

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Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras

Nasser M. Malik, Derek W. Gilroy, Panagiotis S. Kabouridis

FEBS Letters > 2009 > 583 > 1 > 61-69

We describe the development of cell-penetrating inhibitors of Ras and study their ability to inhibit T cell activation. The inhibitors transduced T cells in a time and concentration-dependent manner and interacted with endogenous Ras. Anti-CD3/CD28-activated cells when treated with the inhibitors, exhibited a notable reduction in cell size, diminished proliferative capacity, and were more prone to...

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Lipid rafts and T-lymphocyte function: Implications for autoimmunity

Panagiotis S. Kabouridis, Elizabeth C. Jury

FEBS Letters > 2008 > 582 > 27 > 3711-3718

Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T-lymphocytes, lipid rafts are implicated in signalling from the T-cell antigen receptor (TCR) and in localization and function of proteins residing proximal to the receptor. This...

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Lipid rafts in T cell signalling and disease

Elizabeth C. Jury, Fabian Flores-Borja, Panagiotis S. Kabouridis

Seminars in Cell and Developmental Biology > 2007 > 18 > 5 > 608-615

Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform diverse functions. A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes. In T cells, lipid raft involvement was demonstrated in the early steps during T cell receptor (TCR) stimulation...

article

Biological applications of protein transduction technology

Panagiotis S. Kabouridis

Trends in Biotechnology > 2003 > 21 > 11 > 498-503

The impermeable nature of the cell membrane to peptides, proteins, DNA and oligonucleotides limits the therapeutic potential of these biological agents. However, the recent discovery of short cationic peptides that cross the plasma membrane efficiently is opening up new possibilities for the intracellular delivery of such agents. These peptides are commonly referred to as protein transduction domains...

article

Single chain antibodies specific for fatty acids derived from a semi-synthetic phage display library

Ari Gargir, Itzhak Ofek, Shiri Meron-Sudai, Meital Gal Tanamy, more

BBA - General Subjects > 2002 > 1569 > 1-3 > 167-173

The biological activities of many acylated molecules are lipid dependent. Lipids, however, are poorly immunogenic or non-immunogenic. We employed a phage display semi-synthetic human antibody library to isolate anti-lipid antibodies. Selection was done against methyl palmitate, a 16 carbon aliphatic chain, and a major component of bacterial glycolipids and lipoproteins in animal cells. The selected...

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The role of lipid rafts in T cell antigen receptor (TCR) signalling

Peter W. Janes, Steven C. Ley, Anthony I. Magee, Panagiotis S. Kabouridis

Seminars in Immunology > 2000 > 12 > 1 > 23-34

Copyright 2000 Academic PressPlasma membranes of many cell types contain domains enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell antigen receptor (TCR) signalling molecules associate with rafts, and disrupting raft-association of certain of these abrogates TCR signalling. The TCR itself associates with lipid rafts, and TCR cross-linking causes aggregation...

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