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Ein zellselektives Imaging von Metallionen wird von Lele Li et al. in ihrer Zuschrift auf S. 6370 durch den Einsatz einer enzymaktivierbaren DNAzym‐Sensortechnologie erreicht. Im Bild ist die Sensoraktivität in normalen Zellen stumm und kann in Krebszellen durch ein überexprimiertes Enzym durch ortsspezifische Spaltung wiederhergestellt werden. Der DNAzym‐Sensor ermöglichte die Unterscheidung von...
There is intense interest in imaging intracellular metal ions because of their vital roles in many cellular processes. The challenge has been to develop chemical approaches that can detect metal ions in a cell‐type‐specific manner. Herein we report the design of an enzyme‐activatable DNAzyme sensor technology that can distinguish metal‐ion signals in tumor cells from those in normal cells both in...
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