Search results for: Kamil Piska

Items from 1 to 6 out of 6 results

article

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

Paulina Koczurkiewicz, Katarzyna Klaś, Karolina Grabowska, Kamil Piska, more

Phytotherapy Research > 33 > 9 > 2141 - 2151

Triterpene saponins (saponosides) are found in higher plants and display a wide range of biological and pharmacological activities. The antitumor effects of saponins have been proved by their cytotoxic, cytostatic, proapoptotic, and anti‐invasive effects in many cellular models. Saponins hold great potential for being developed into chemopreventive and chemotherapeutic drugs. A promising way of reducing...

article

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

Agnieszka Zagórska, Anna Partyka, Adam Bucki, Marcin Kołaczkowski, more

Chemical Biology & Drug Design > 93 > 4 > 511 - 521

A series of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione has been synthesized in an attempt to discover a new class of psychotropic agents. Compounds were evaluated for their in vitro affinity for serotonin 5‐HT_1A, 5‐HT₇, and phosphodiesterases PDE4 and PDE10. The most potent compound 2‐pyrimidinyl‐1‐piperazinyl‐butyl‐imidazo[2,1‐f]purine‐2,4‐dione (4b) behaved...

article

Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review

Kamil Piska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, more

European Journal of Medicinal Chemistry > 2018 > 156 > C > 13-20

Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L. (long piper), a medical plant known from Ayurvedic medicine. Although was discovered well over fifty years ago, its pharmacological properties have been uncovered in the past decade. In particular, piperlongumine has been most extensively studied as a potential anticancer agent. Piperlongumine has exhibited cytotoxicity...

article

Enhanced production of the pharmaceutically important polyphenolic compounds in Vitex agnus castus L. shoot cultures by precursor feeding strategy

Ewa Skrzypczak‐Pietraszek, Kamil Piska, Jacek Pietraszek

Engineering in Life Sciences > 18 > 5 > 287 - 297

Agitated Vitex agnus castus L. shoot cultures were established to analyse the content of selected pharmaceutically important flavonoids and phenolic acids. Two variants (selected from nine ones) of MS medium were prepared: A (BAP 1 mg/L; NAA 0.5 mg/L; GA₃ 0.25 mg/L) and B (BAP 2 mg/L; NAA 0.5 mg/L). The biomass was harvested after 1, 2, 3,4, 5 and 6 weeks. Four‐week cultures (variant A) were selected...

article

Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Kamil Piska, Paulina Koczurkiewicz, Adam Bucki, Katarzyna Wójcik-Pszczoła, more

Investigational New Drugs > 2017 > 35 > 3 > 375-385

Summary Anthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. Possible mechanisms of ANT cardiotoxicity include their conversion to secondary alcohol metabolites (i.e. doxorubicinol, daunorubicinol) catalyzed by...

article

Two new triterpenoid saponins from the leaves of Impatiens parviflora DC. and their cytotoxic activity

Karolina Grabowska, Irma Podolak, Agnieszka Galanty, Paweł Żmudzki, more

Industrial Crops and Products > 2017 > 96 > C > 71-79

Two new triterpene saponins, camelliagenin A derivatives, were isolated from the leaves of Impatiens parviflora DC. (Balsaminaceae). Their structures were determined based on a combination of one- and two-dimensional nuclear magnetic resonance (NMR) techniques, and mass spectrometry, as 3-O-{[β-d-glucopyranosyl-(1→3)-]-[β-d-glucopyranosyl-(1→2)]}- β-d-glucuronopyranoside 16-O-acetyl-3β,22α,28-trihydroxy-olean-12-ene...

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Search results for: Kamil Piska

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review

Enhanced production of the pharmaceutically important polyphenolic compounds in Vitex agnus castus L. shoot cultures by precursor feeding strategy

Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Two new triterpenoid saponins from the leaves of Impatiens parviflora DC. and their cytotoxic activity

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