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Protein arginine methyltransferase 1 (PRMT1) stimulates erythroid differentiation, but the signaling events upstream are yet to be identified. Ca2+ plays crucial roles during erythroid differentiation. Here, we show that Ca2+ enhances methylation during induced erythroid differentiation and that Ca2+ directly upregulates the catalytic activity of recombinant PRMT1 by increasing Vmax toward the substrate...
CD1d-deficient (CD1d -/- ) mouse lymphocytes were analyzed to classify the natural killer T (NKT) cells without reactivity to CD1d. The cells bearing a Vα19.1-Jα26 (AV19-AJ33) invariant TCR α chain, originally found in the peripheral blood lymphocytes, were demonstrated to be abundant in the NK1.1 + but not NK1.1 - T cell population isolated from CD1d -/...
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