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The antispastic triazole, 4-methyl-3-methylsulphonyl-5-phenyl-4H-1,2,4-triazole (MDL 27 531) was tested in glycine- and muscimol-stimulated 36 Cl - influx into brain membrane preparations. MDL 27 531 (100 nM) had no effect on glycine- (100 nM-400 μM) stimulated 36 Cl - influx in brain stem tissue; on the other hand, MDL 27 531 (10 nM-10 μM) enhanced muscimol-...
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