Search results for: B. Major

Items from 1 to 20 out of 119 results

article

Implementing Health Care Quality Measures in Electronic Health Records: A Conceptual Model

Claire M. Campbell, Daniel R. Murphy, George E. Taffet, Anita B. Major, more

Journal of the American Geriatrics Society > 69 > 4 > 1079 - 1085

Background/Objectives There is significant literature on the development and validation of quality measures, but comparably less on their implementation into learning health systems. Electronic Health Records (EHRs) have made vast amounts of data available for quality improvement purposes. In this paper we describe a conceptual model for EHR implementation of quality measures. Design The model...

article

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

Brittany M Bowman, Stephanie A Montgomery, Travis P Schrank, Jeremy M Simon, more

The Journal of Pathology > 252 > 2 > 125 - 137

Activation of the nuclear factor (erythroid‐derived 2)‐like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas...

article

The MyMOMA domain of MYO19 encodes for distinct Miro‐dependent and Miro‐independent mechanisms of interaction with mitochondrial membranes

Jennifer L. Bocanegra, Barbara M. Fujita, Natalie R. Melton, James M. Cowan, more

Cytoskeleton > 77 > 3-4 > 149 - 166

MYO19 interacts with mitochondria through a C‐terminal membrane association domain (MyMOMA). Specific mechanisms for localization of MYO19 to mitochondria are poorly understood. Using promiscuous biotinylation data in combination with existing affinity‐capture databases, we have identified a number of putative MYO19‐interacting proteins. We chose to explore the interaction between MYO19 and the mitochondrial...

article

Cloud access to interoperable IVOA-compliant VOSpace storage

S. Bertocco, P. Dowler, S. Gaudet, B. Major, more

Astronomy and Computing > 2018 > 24 > C > 36-44

Handling, processing and archiving the huge amount of data produced by the new generation of experiments and instruments in Astronomy and Astrophysics are among the more exciting challenges to address in designing the future data management infrastructures and computing services. We investigated the feasibility of a data management and computation infrastructure, available world-wide, with the aim...

article

Wear mechanisms of the biotribological nanocomposite a‐C : H coatings implanted by metallic nanoparticles

L. MAJOR, M. JANUSZ, J.M. LACKNER, M. KOT, more

Journal of Microscopy > 268 > 1 > 94 - 104

Recently, to reduce the residual stress and increase the mechanical properties of a‐C:H coatings, metallic nanoparticles have been implanted into their structure. In the present work, to improve the properties of the coating, metallic nanoparticles, including Cu, Nb, Ta, Zr, AgPt and Ag, were inserted into the a‐C:H structure. The applied biological and mechanical analysis allowed the optimal biotribological...

chapter

Investigation of high harmonic generation using a high-power, 5-fs laser in a loose-focusing geometry

B. Major, D. E. Rivas, B. Bergues, M. Weidman, more

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) > 1

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)

Since its first observation almost three decades ago high-order harmonic generation (HHG) in gases became a reliable source of extreme ultraviolet (XUV) pulses, which gave the possibility to study electronic processes on their natural timescale [1, 2]. While the main building blocks of the experimental setups for gas HHG are the same in almost all cases, the focusing or medium geometry varies from...

article

Microstructure characterization of advanced protective Cr/CrN+a‐C:H/a‐C:H:Cr multilayer coatings on carbon fibre composite (CFC)

L. MAJOR, M. JANUSZ, J.M. LACKNER, M. KOT, more

Journal of Microscopy > 262 > 3 > 191 - 202

Studies of advanced protective chromium‐based coatings on the carbon fibre composite (CFC) were performed. Multidisciplinary examinations were carried out comprising: microstructure transmission electron microscopy (TEM, HREM) studies, micromechanical analysis and wear resistance. Coatings were prepared using a magnetron sputtering technique with application of high‐purity chromium and carbon (graphite)...

article

Weight loss reduces basal-like breast cancer through kinome reprogramming

Yuanyuan Qin, Sneha Sundaram, Luma Essaid, Xin Chen, more

Cancer Cell International > 2016 > 16 > 1 > 1-13

Background Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). BBC has no targeted therapies, making the need for mechanistic insight urgent. Reducing adiposity in adulthood can lower incidence of BBC in humans. Thus, this study investigated whether a dietary intervention to reduce adiposity prior to tumor onset would reverse HFD-induced BBC. ...

article

Development of surface modification methods for ReligaHeart® cardiac support system

R. Major, R. Kustosz, K. Trembecka-Wójciga, J. M. Lackner, more

Archives of Metallurgy and Materials > 2016 > Vol. 61, iss. 3 > 1399--1404

The work is a review of the methods of the surface modification performed by the authors dedicated for for cardiac support system. It presents the evolution of designing the surface dedicated to direct contact with blood. Initially thin and ultrathin coatings were developed. They were designed as a blood-polymer barrier. The pneumatic heart assist devices are made of a medical grade polyurethane....

article

Contribution of titanium, chromium and carbon buffer interlayers to bio-tribological properties of multilayer composites

Ł. Major, M. Janusz, J. M. Lackner, B. Major

Archives of Metallurgy and Materials > 2016 > Vol. 61, iss. 3 > 1391--1398

Research studies on bio-tribological protective coatings of titanium, chromium and carbon based have been performed. Thin films were fabricated by hybrid PLD technique (PLD supported by magnetron sputtering). Coatings consisted of two parts; the inner part (first from the substrate) in each case was formed by titanium or chromium/titanium nitride or chromium nitride (Ti/TiN or Cr/Cr₂N). The outer...

article

A method for segregating the optical absorption properties and the mass concentration of winter time urban aerosol

T. Ajtai, N. Utry, M. Pintér, B. Major, more

Atmospheric Environment > 2015 > 122 > C > 313-320

A novel in-situ, real time method for the determination of inherent absorption properties of light absorbing carbonaceous particulate matter and its possible application for source apportionment are introduced here. The method is deduced from a two-week campaign under wintry urban conditions during which strong correlation was found between aerosol number size distribution and wavelength dependent...

article

Combining efficacy and toxicity effect sizes from randomized clinical trials (RCTs) into an interpretable quality-adjusted effect size estimate in patients with Multiple Myeloma (MM)

B. Major, J. Sloan, A. Dispenzieri

Clinical Lymphoma Myeloma and Leukemia > 2015 > 15 > Supplement 3 > e62-e63

article

Dry And Ringer Solution Lubricated Tribology Of Thin Osseoconductive Metal Oxides And Diamond-Like Carbon Films

W. Waldhauser, J. M. Lackner, M. Kot, B. Major

Archives of Metallurgy and Materials > 2015 > Vol. 60, iss. 3 > 2139-2144

Achieving fast and strong adhesion to jawbone is essential for dental implants. Thin deposited films may improve osseointegration, but they are prone to cohesive and adhesive fracture due to high stresses while screwing the implant into the bone, leading to bared, less osteoconductive substrate surfaces and nano- and micro-particles in the bone. Aim of this work is the investigation of the cohesion...

article

Biomechanical properties of the thin PVD coatings defined by red blood cells

K. Trembecka-Wojciga, R. Major, J. M. Lackner, F. Bruckert, more

Bulletin of the Polish Academy of Sciences. Technical Sciences > 2015 > Vol. 63, nr 3 > 697--705

The measurement of the strength of bonds between biomaterials and cells is a major challenge in biotribology since it allows for the identification of different species in adhesion phenomena. Biomaterials, such as diamond-like carbon (DLC), titanium, and titanium nitride, seem to be good candidates for future blood-contact applications. These materials were deposited as thin films by the hybrid pulsed...

article

Computer engineering in designing and fabrication of tissue analogue-type coating dedicated for the cardiovascular regeneration

K. Trembecka-Wojciga, R. Major, F. Bruckert, J.M. Lackner, more

Archives of Civil and Mechanical Engineering > 2015 > 15 > 3 > 621-630

The work was related to the development of novel methods in designing and fabrication of thin, porous, tissue-like coatings. The surface modification was designed to create an environment for the appropriate cell growth. The originally designed system was established to prepare porous, synthetic coatings. The dedicated software was elaborated to control the sequential coating deposition based on the...

article

Computer engineering in designing and fabrication of tissue analogue-type coating dedicated for the cardiovascular regeneration

K. Trembecka-Wojciga, R. Major, F. Bruckert, J. M. Lackner, more

Archives of Civil and Mechanical Engineering > 2015 > Vol. 15, no. 3 > 621--630

article

Roughness Influence on Macro- and Micro-Tribology of Multi-Layered Hard Coatings on Carbon Fibre Polymer Composite

J. M. Lackner, B. Major, W. Waldhauser, A. Mzyk, more

Archives of Metallurgy and Materials > 2015 > Vol. 60, iss. 3 > 2145--2151

Goal of this work is the investigation of roughness influences on the abrasive wear behaviour of magnetron sputtered multi- -layered, low-friction coatings on carbon-fibre reinforced polymers (CFRP). Higher coating roughness at similar CFRP quality was realized by higher deposition rates, leading to increased heat flux to the substrates during deposition. Thermal expansion of the epoxy matrix on the...

article

Graphene based porous coatings with antibacterial and antithrombogenous function—Materials and design

R. Major, M. Sanak, A. Mzyk, L. Lipinska, more

Archives of Civil and Mechanical Engineering > 2014 > 14 > 4 > 540-549

The studies considered graphene-based biomaterials dedicated for cardiovascular therapy. Reduced graphene oxide flakes were introduced into the porous structure of the polyelectrolyte based coatings. TEM analysis showed the presence of graphene flakes arranged parallel to the substrate surface, firmly connected to the porous coating. Biomaterials were subjected to a comprehensive diagnosis of the...

article

Chemical control of polyelectrolyte film properties for an effective cardiovascular implants endothelialization

A. Mzyk, R. Major, M. Kot, J. Gostek, more

Archives of Civil and Mechanical Engineering > 2014 > 14 > 2 > 262-268

The aim of this study was to improve properties of blood contacting materials such as polyurethane, in a form of intelligent, self-organizing and self-controlling coatings, which allow the selective mobilization and colonization of the endothelial cells on their surface. The prepared multilayer polyelectrolyte scaffolds were cross-linked chemically by EDC/NHS reagents in order to control their physicochemical...

article

Człowiek o wielkiej inwencji naukowej

B. Major

Zeszyty Historyczne Politechniki Warszawskiej > 2014 > z. 15 > 19--22

Forum Akademickie, dodatek: 2013 Rok Czochralskiego pod red. M. Nadera i P. Kieracińskiego, 2013, s. 8-9

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INFONA - science communication portal

Search results for: B. Major

Implementing Health Care Quality Measures in Electronic Health Records: A Conceptual Model

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

The MyMOMA domain of MYO19 encodes for distinct Miro‐dependent and Miro‐independent mechanisms of interaction with mitochondrial membranes

Cloud access to interoperable IVOA-compliant VOSpace storage

Wear mechanisms of the biotribological nanocomposite a‐C : H coatings implanted by metallic nanoparticles

Investigation of high harmonic generation using a high-power, 5-fs laser in a loose-focusing geometry

Microstructure characterization of advanced protective Cr/CrN+a‐C:H/a‐C:H:Cr multilayer coatings on carbon fibre composite (CFC)

Weight loss reduces basal-like breast cancer through kinome reprogramming

Development of surface modification methods for ReligaHeart® cardiac support system

Contribution of titanium, chromium and carbon buffer interlayers to bio-tribological properties of multilayer composites

A method for segregating the optical absorption properties and the mass concentration of winter time urban aerosol

Combining efficacy and toxicity effect sizes from randomized clinical trials (RCTs) into an interpretable quality-adjusted effect size estimate in patients with Multiple Myeloma (MM)

Dry And Ringer Solution Lubricated Tribology Of Thin Osseoconductive Metal Oxides And Diamond-Like Carbon Films

Biomechanical properties of the thin PVD coatings defined by red blood cells

Computer engineering in designing and fabrication of tissue analogue-type coating dedicated for the cardiovascular regeneration

Computer engineering in designing and fabrication of tissue analogue-type coating dedicated for the cardiovascular regeneration

Roughness Influence on Macro- and Micro-Tribology of Multi-Layered Hard Coatings on Carbon Fibre Polymer Composite

Graphene based porous coatings with antibacterial and antithrombogenous function—Materials and design

Chemical control of polyelectrolyte film properties for an effective cardiovascular implants endothelialization

Człowiek o wielkiej inwencji naukowej

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