The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The American Society for Histocompatibility and Immunogenetics HLA common and well‐documented (CWD) catalog, CWD 2.0.0 catalog and European Federation for Immunogenetics (EFI) CWD catalog have been published, which are useful for improving the accuracy of HLA genotyping in laboratories. Here, we studied the Chinese HLA CWD catalog. A total of 812 211 unrelated volunteer donors from the China Marrow...
Interferon (IFN) activation signaling and T helper 17 (Th17)‐cell/B‐cell regulation play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Several studies have provided convincing evidence that polymorphisms in IRF5, STAT4, IKZF1 and ETS1 from these pathways may be involved in SLE by affecting gene expression or epistasis. We analyzed the genetic interaction in known SLE susceptibility...
In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01‐DQA1*01:02‐DQB1*06:02 haplotype. Studies in African‐Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, we...
Two hundred and thirty‐six novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the China Marrow Donor Program: 71 HLA‐A alleles, 79 HLA‐B alleles, 43 HLA‐C, 16 HLA‐DRB1 alleles, 26 HLA‐DQB1 and 1 HLA‐DPB1. Two hundred and thirteen (90.3%) of the 236 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Seventy‐eight...
The HLA‐A*31:01:09 differs from the closest allele HLA‐A*31:01:02 by a C to T silent substitution at position 447 in exon 3. The HLA‐A*33:30 differs from the closest allele HLA‐A*33:03:01 by a single nucleotide substitution at position 453 in exon 3, leading to a change of Arg131Cys.
The HLA‐DRB1*15:02:08 allele differs from the closest allele HLA‐DRB1*15:02:01 by a single synonymous nucleotide change at position 116 in exon 2 from C to T.
The nucleotide sequence of HLA‐B*35:42:02 has a single nucleotide difference at position 141 C>T compared with that of HLA‐B*35:42:01, which does not result in an amino acid change.
Abstract
The HLA‐B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27‐subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27‐subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case‐control association study, and...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.