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Biotechnological manufacturing processes often include a bioreactor harvesting step which involves separation of cells, cell debris and other particulate matter from the suspending medium which frequently contains the product of interest. Tangential flow microfiltration is used to separate the particulate matter from the suspending medium. The efficiency of this microfiltration step is often improved...
Deposition of the rejected species on the membrane surface during tangential flow microfiltration is often observed. This cake layer can lead to lower permeate fluxes and partial rejection of dissolved solutes. Flocculation of the feed stream prior to microfiltration has been shown to increase the volume-based modal particle size which in turn leads to increased permeate fluxes. Relating the properties...
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