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La biodistribution des oligonucleotides (ON) depend en partie des modifications chimiques (liaisons internucleotides et modifications terminales) destinees a ralentir leur rapide destruction par les nucleases in vivo. L' etude de la cinetique isotopique in vivo de differents ON modifies peut apporter une contribution utile a l'etude de leur repartition biologique.But: Etudier la repartition differentielle...
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