Search results for: D. Roberts

Items from 1 to 20 out of 848 results

article

Sensitivity of ECMWF coupled forecasts to improved initialization of the ocean mesoscale

Christopher D. Roberts, Magdalena A. Balmaseda, Steffen Tietsche, Frederic Vitart

Quarterly Journal of the Royal Meteorological Society > 148 > 749 > 3694 - 3714

It has been hypothesized that initial conditions derived from eddy‐resolving ocean models could benefit eddy‐permitting forecast systems at subseasonal lead times (

\sim

2 weeks to

\sim

2 months) by providing improved ocean initial conditions and reduced sea‐surface temperature (SST) errors associated with a more realistic representation of mesoscale features and ocean fronts such as the...

article

Characterizing the metabolic role of STAT3 in canine osteosarcoma

Heather L. Gardner, Joelle M. Fenger, Ryan D. Roberts, Cheryl A. London

Veterinary and Comparative Oncology > 20 > 4 > 817 - 824

Signal transducer and activator of transcription 3 (STAT3) dysregulation has been characterized in canine OS, with previous data suggesting that constitutive STAT3 activation contributes to survival and proliferation in OS cell lines in vitro. Recently, the contribution of STAT3 to tumour metabolism has been described across several tumour histologies, and understanding the metabolic implications...

article

Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area

Bradley A. Ruple, Paulo. H. C. Mesquita, Joshua S. Godwin, Casey L. Sexton, more

Experimental Physiology > 107 > 11 > 1216 - 1224

New Findings What is the central question of this study? Do changes in myofibre cross‐sectional area, pennation angle and fascicle length predict vastus lateralis whole‐muscle cross‐sectional area changes following resistance training? What is the main finding and its importance? Changes in vastus lateralis mean myofibre cross‐sectional area, fascicle length and pennation angle following a period...

article

Strategic Applications of the β‐Silicon Effect

Dean D. Roberts, Mark G. McLaughlin

Advanced Synthesis & Catalysis > 364 > 14 > 2307 - 2332

Organosilicon reagents are highly versatile and privileged scaffolds in modern synthetic chemistry, largely due to the range of transformations the groups are amenable to. The β‐Silicon effect is one of the fundamental phenomena underpinning the inherent reactivity of organosilicon reagents, allowing unsaturated organosilanes to undergo a range of electrophilic substitutions with a variety of nucleophiles...

article

Challenges and solutions for diabetes early career researchers in the COVID‐19 recovery: Perspectives of the Diabetes UK Innovators in Diabetes

Matthew C. Gage, Deirdre Harrington, Gemma V. Brierley, Rachel M. Freathy, more

Diabetic Medicine > 39 > 3 > n/a - n/a

article

Tissue predictability of elastography is low in collagenase induced deep digital flexor tendinopathy

Sherry A. Johnson, Elizabeth W. Biscoe, Kirsten E. Eilertson, John D. Lutter, more

Veterinary Radiology & Ultrasound > 63 > 1 > 111 - 123

Elastography is an emerging imaging modality for characterizing tendon injury in horses, but its ability to differentiate tissue deformability relative to treatment group and biochemical properties using a prospective, experimental study design remain unknown. Objectives of the current study were to (a) to investigate differences in glycosaminoglycan, DNA, and soluble collagen levels in mesenchymal...

article

More accuracy with less precision

Simon T. K. Lang, Andrew Dawson, Michail Diamantakis, Peter Dueben, more

Quarterly Journal of the Royal Meteorological Society > 147 > 741 > 4358 - 4370

Reducing the numerical precision of the forecast model of the Integrated Forecasting System (IFS) of the European Centre for Medium‐Range Weather Forecasts (ECMWF) from double to single precision results in significant computational savings without negatively affecting forecast accuracy. The computational savings allow to increase the vertical resolution of the operational ensemble forecasts from...

article

A systematic review of surfactant delivery via laryngeal mask airway, pharyngeal instillation, and aerosolization: Methods, limitations, and outcomes

Usha Devi, Kari D. Roberts, Aakash Pandita

Pediatric Pulmonology > 57 > 1 > 9 - 19

Less invasive surfactant administration methods without laryngoscopy and endotracheal catheterization include delivery via laryngeal mask airway, pharyngeal instillation, and aerosolization. These less invasive techniques are promising and have several advantages over INSURE (Intubation‐Surfactant‐Extubation) and thin catheter techniques. The objective of this review is to discuss the requisites,...

article

Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case–control study

L Goodfellow, MC Verwijs, A Care, A Sharp, more

BJOG: An International Journal of Obstetrics & Gynaecology > 128 > 13 > 2061 - 2072

Objective To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes (PPROM). Design Nested case–control study. Setting UK tertiary referral hospital. Sample High‐risk women with previous sPTB/PPROM <34⁺⁰ weeks’ gestation who had a recurrence (n = 22) or delivered at ≥37⁺⁰ weeks without...

article

Functional beta diversity of New Zealand fishes: Characterising morphological turnover along depth and latitude gradients, with derivation of functional bioregions

Elisabeth M. V. Myers, David Eme, Libby Liggins, Euan S. Harvey, more

Austral Ecology > 46 > 6 > 965 - 981

Changes in the functional structures of communities are rarely examined along multiple large‐scale environmental gradients. Here, we describe patterns in functional beta diversity for New Zealand marine fishes versus depth and latitude, including broad‐scale delineation of functional bioregions. We derived eight functional traits related to food acquisition and locomotion and calculated complementary...

article

Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force

Sarah B. Whittle, Katharine Offer, Ryan D. Roberts, Amy LeBlanc, more

Pediatric Blood & Cancer > 68 > 9 > n/a - n/a

Osteosarcoma is the most common bone tumor in children and young adults. Metastatic and relapsed disease confer poor prognosis, and there have been no improvements in outcomes for several decades. The disease's biological complexity, lack of drugs developed specifically for osteosarcoma, imperfect preclinical models, and limits of existing clinical trial designs have contributed to lack of progress...

article

Feasibility, long‐term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

Paul N. Harden, David S. Game, Birgit Sawitzki, Jeroen B. Van der Net, more

American Journal of Transplantation > 21 > 4 > 1603 - 1611

Short‐term outcomes in kidney transplantation are marred by progressive transplant failure and mortality secondary to immunosuppression toxicity. Immune modulation with autologous polyclonal regulatory T cell (Treg) therapy may facilitate immunosuppression reduction promoting better long‐term clinical outcomes. In a Phase I clinical trial, 12 kidney transplant recipients received 1–10 × 10⁶ Treg per...

article

Larval cross‐shore transport estimated from internal waves with a background flow: The effects of larval vertical position and depth regulation

Jessica C. Garwood, Andrew J. Lucas, Perry Naughton, Paul L. D. Roberts, more

Limnology and Oceanography > 66 > 3 > 678 - 693

Cross‐shore velocities in the coastal ocean typically vary with depth. The direction and magnitude of transport experienced by meroplanktonic larvae will therefore be influenced by their vertical position. To quantify how swimming behavior and vertical position in internal waves influence larval cross‐shore transport in the shallow (~ 20 m), stratified coastal waters off Southern California, we deployed...

article

The representation of winter Northern Hemisphere atmospheric blocking in ECMWF seasonal prediction systems

Paolo Davini, Antje Weisheimer, Magdalena Balmaseda, Stephanie J. Johnson, more

Quarterly Journal of the Royal Meteorological Society > 147 > 735 > 1344 - 1363

The simulation and prediction of winter Northern Hemisphere atmospheric blocking in the seasonal prediction systems from the European Centre for Medium‐Range Weather Forecasts (ECMWF) is analysed. Blocking statistics from the operational November‐initialised seasonal hindcasts are evaluated in three generations of models: System3, System4, and System5 (SEAS5). Improvements in the climatological representation...

article

Associations between social and behavioural factors and the risk of late stillbirth – findings from the Midland and North of England Stillbirth case‐control study

AEP Heazell, J Budd, LK Smith, M Li, more

BJOG: An International Journal of Obstetrics & Gynaecology > 128 > 4 > 704 - 713

Objective To investigate behavioural and social characteristics of women who experienced a late stillbirth compared with women with ongoing live pregnancies at similar gestation. Design Case‐control study. Setting 41 maternity units in the UK. Population Women who had a stillbirth ≥28 weeks’ gestation (n = 287) and women with an ongoing pregnancy at the time of interview (n = 714). Methods...

article

A simple maneuver to determine if septal accessory pathway ablation requires a left atrial approach

Juliana Kanawati, Jason D. Roberts, Matthew K. Rowe, Habib Khan, more

Journal of Cardiovascular Electrophysiology > 31 > 12 > 3207 - 3214

Introduction Septal accessory pathway (AP) ablation can be challenging due to the complex anatomy of the septal region. The decision to access the left atrium (LA) is often made after failure of ablation from the right. We sought to establish whether the difference between ventriculo‐atrial (VA) time during right ventricular (RV) apical pacing versus the VA during tachycardia would help establish...

article

The evolution of gene‐guided management of inherited arrhythmia syndromes: Peering beyond monogenic paradigms towards comprehensive genomic risk scores

Matthew K. Rowe, Jason D. Roberts

Journal of Cardiovascular Electrophysiology > 31 > 11 > 2998 - 3008

Inherited arrhythmia syndromes have traditionally been viewed as monogenic forms of disease whose pathophysiology is driven by a single highly penetrant rare genetic variant. Although an accurate depiction of a proportion of genetic variants, the variable penetrance frequently noted in genotype positive families and the presence of sporadic genotype negative cases have long highlighted a more nuanced...

article

Environmental drivers of population variability in colony‐forming marine diatoms

Kasia M. Kenitz, Eric C. Orenstein, Paul L. D. Roberts, Peter J. S. Franks, more

Limnology and Oceanography > 65 > 10 > 2515 - 2528

Many aquatic microbes form colonies, yet little is known about their abundance and fitness relative to single‐celled taxa. The formation of diatom chains, in particular, has implications for diatom growth, survival, and carbon transfer. Here, we utilize an autonomous underwater microscope, combined with traditional microscopy, to develop a novel, multiyear record of the abundance of single‐cell and...

article

A novel cross‐shore transport mechanism revealed by subsurface, robotic larval mimics: Internal wave deformation of the background velocity field

Jessica C. Garwood, Andrew J. Lucas, Perry Naughton, Matthew H. Alford, more

Limnology and Oceanography > 65 > 7 > 1456 - 1470

Coastal physical processes are essential for the cross‐shore transport of meroplanktonic larvae to their benthic adult habitats. To investigate these processes, we released a swarm of novel, trackable, subsurface vehicles, the Mini‐Autonomous Underwater Explorers (M‐AUEs), which we programmed to mimic larval depth‐keeping behavior. The M‐AUE swarm measured a sudden net onshore transport of 30–70 m...

article

An evolutionary framework for treating pediatric sarcomas

Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, more

Cancer > 126 > 11 > 2577 - 2587

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INFONA - science communication portal

Search results for: D. Roberts

Sensitivity of ECMWF coupled forecasts to improved initialization of the ocean mesoscale

Characterizing the metabolic role of STAT3 in canine osteosarcoma

Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area

Strategic Applications of the β‐Silicon Effect

Challenges and solutions for diabetes early career researchers in the COVID‐19 recovery: Perspectives of the Diabetes UK Innovators in Diabetes

Tissue predictability of elastography is low in collagenase induced deep digital flexor tendinopathy

More accuracy with less precision

A systematic review of surfactant delivery via laryngeal mask airway, pharyngeal instillation, and aerosolization: Methods, limitations, and outcomes

Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case–control study

Functional beta diversity of New Zealand fishes: Characterising morphological turnover along depth and latitude gradients, with derivation of functional bioregions

Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force

Feasibility, long‐term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

Larval cross‐shore transport estimated from internal waves with a background flow: The effects of larval vertical position and depth regulation

The representation of winter Northern Hemisphere atmospheric blocking in ECMWF seasonal prediction systems

Associations between social and behavioural factors and the risk of late stillbirth – findings from the Midland and North of England Stillbirth case‐control study

A simple maneuver to determine if septal accessory pathway ablation requires a left atrial approach

The evolution of gene‐guided management of inherited arrhythmia syndromes: Peering beyond monogenic paradigms towards comprehensive genomic risk scores

Environmental drivers of population variability in colony‐forming marine diatoms

A novel cross‐shore transport mechanism revealed by subsurface, robotic larval mimics: Internal wave deformation of the background velocity field

An evolutionary framework for treating pediatric sarcomas

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