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We report the development of magnetically-driven, 100µm in typical diameter, core-shell microcapsules for the on-demand and local delivery of encapsulated drug agents. These microcapsules are fabricated through a multi-stage microfluidic/optofluidic flow-focusing device with oil-based core and thermoresponsive polymer shell. In the prototype capsules, the shell structure is constructed by UV-curable...
This work marks the first use of in-situ photopolymerization to create single-layer microfluidic devices which serve as ultra-low Reynolds Number (Re) current sources to regulate fluid flow rate independent of operating pressures. Autonomous fluidic components are an emerging aspect of micro/nanofluidic circuits and applications; however, many existing fluidic applications require specific pressure...
‘Human-powered’ microdroplet generators are ideal for droplet-based point-of-care diagnostics applications. Here we present a versatile ‘finger-powered’ microdroplet generator. The prototype system was fabricated via polymer-based micromachining processes. In this work, we have achieved: (1) the use of a human finger as the actuation force for droplet generation, (2) an integrated pumping system for...
A lithography-free microchannel fabrication process with controlled pattern is demonstrated via the combination of Near Field Electrospinning (NFES) and molding of polydimethysiloxane (PDMS). Electrospun polymer fibers (1–10µm in width, 0.5–4µm in height) were patterned onto a silicon substrate to serve as the template. Microfluidic devices with parallel and grid-pattern microchannels were created...
Here we present and demonstrate the concept of a versatile `human-powered' fluid pumps as a modular element to provide pressure head for a variety of microfluidic systems. Several distinctive accomplishments have been achieved: (1) human finger as the pumping actuation force; (2) pumping without using any electricity, (3) integrated pump with a passive safety valve and two one-way valves, and (4)...
Dynamic bead-based microarrays offer an ideal platform for chemical and biological applications, including on-site chemical analysis, point-of-care medical diagnostics and synthetic biology on a chip. Despite significant development of dynamic microarrays, challenges have remained for achieving multi-stage fluidic reactions and analyses. Here we present a novel bead-based microarray platform - Microfluidic...
The dynamics of a high heat flux thermal bubble is constrained by the thermal energy carried on the bubble surface right after the bubble formation because of thermal isolation of vapor. This article proposes a way by assigning time delays between dual bubbles to transfer effectively energy from one bubble into the other, thus, breaks energy limitation that one single bubble can usually carry. Experiment...
This paper reports the first demonstration of single nucleotide polymorphism (SNP) genotyping via molecular beacon probes immobilized on polystyrene microbead substrates within a dynamic microfluidic system. Additionally, we present an optimized bead immobilization technique, micropost array trapping (muPAT), for high-density and high-throughput arraying of beads. Quantitative detection was achieved...
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