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One of the most characteristic brain lesions of Alzheimer disease is the accumulation of paired helical filaments (PHF) in the affected neurons. The PHF are prominent in all the three major disease lesions, namely the neurofibrillary tangles, the neuropil threads and the neuritic (senile) plaques. The microtubule associated protein tau in abnormally hyperphosphorylated form is the major protein subunit...
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