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Phenotypic variations in α‐thalassemia mainly depend on the defective α‐globin gene number. Genetic modifiers of the phenotype of Hemoglobin H (HbH) disease were poorly reported, apart from β‐thalassemia allele that was identified ameliorating the severity of α‐thalassemia. Because erythroid Krüppel‐like factor (KLF1) mutations can modulate the red blood phenotype, we evaluated its effect on the α‐thalassemia...
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