Search results for: Anupam Bandyopadhyay

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article

Capturing Sialyl‐glycan on Live Cancer Cells by Tailored Boronopeptide**

Saurav Chatterjee, Arnab Chowdhury, Sheetanshu Saproo, Nitesh Mani Tripathi, more

Chemistry – A European Journal > 30 > 8 > n/a - n/a

Boronic acid‐containing molecules are substantially popularized in chemical biology and medicinal chemistry due to the broad spectrum of covalent conjugations as well as interaction modules offered by the versatile boron atom. Apparently, the WGA peptide (wheat germ agglutinin, 62–73), which shows a considerably low binding affinity to sialic acid, turned into a selective and >5 folds potent binder...

article

Sulfonyl Diazaborine ‘Click’ Chemistry Enables Rapid and Efficient Bioorthogonal Labeling**

Arnab Chowdhury, Saurav Chatterjee, Apoorv Kushwaha, Sidhanta Nanda, more

Chemistry – A European Journal > 29 > 41 > n/a - n/a

Finding an ideal bioorthogonal reaction that responds to a wide range of biological queries and applications is of great interest in biomedical applications. Rapid diazaborine (DAB) formation in water by the reactions of ortho‐carbonyl phenylboronic acid with α‐nucleophiles is an attractive conjugation module. Nevertheless, these conjugation reactions demand to satisfy stringent criteria for bioorthogonal...

article

Targeting biomolecules with reversible covalent chemistry

Anupam Bandyopadhyay, Jianmin Gao

Current Opinion in Chemical Biology > 2016 > 34 > C > 110-116

Interaction of biomolecules typically proceeds in a highly selective and reversible manner, for which covalent bond formation has been largely avoided due to the potential difficulty of dissociation. However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inhibitors that serve as powerful therapeutics, as well as molecular probes with exquisite target selectivity...

article

Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of α‐Nucleophiles at Neutral pH

Anupam Bandyopadhyay, Jianmin Gao

Chemistry – A European Journal > 21 > 42 > 14748 - 14752

Bioorthogonal reactions that are fast and reversible under physiological conditions are in high demand for biological applications. Herein, it is shown that an ortho boronic acid substituent makes aryl ketones rapidly conjugate with α‐nucleophiles at neutral pH. Specifically, 2‐acetylphenylboronic acid and derivatives were found to conjugate with phenylhydrazine with rate constants of 10² to 10³ M...

article

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

Anupam Bandyopadhyay, Sachitanand M. Mali, Pooja Lunawat, K. Muruga Poopathi Raja, more

Organic Letters > 2011 > 13 > 17 > 4482 - 4485

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Search results for: Anupam Bandyopadhyay

Capturing Sialyl‐glycan on Live Cancer Cells by Tailored Boronopeptide**

Sulfonyl Diazaborine ‘Click’ Chemistry Enables Rapid and Efficient Bioorthogonal Labeling**

Targeting biomolecules with reversible covalent chemistry

Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of α‐Nucleophiles at Neutral pH

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

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