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Many clinical trials for cancer precision medicine have yielded unsatisfactory results due to challenges such as drug resistance and low efficacy. Drug resistance is often caused by the complex compensatory regulation within the biomolecular network in a cancer cell. Recently, systems biological studies have modeled and simulated such complex networks to unravel the hidden mechanisms of drug resistance...
Systems‐biology can identify novel drug targets through computational analysis of cellular regulatory networks, and nanomaterial engineering can develop nanocarriers to deliver therapeutic agents to the specific target of cancer cells. In article number 1906783, Kwang‐Hyun Cho and co‐workers review the recent progress and challenges in systems biology and nanomedicine and their integration with a...
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