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The in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F‐AuNSs) conjugated with antibodies and 64Cu radiolabels in vivo and in artificial lysosomal fluid ex vivo, is shown. The short‐term biodistribution of F‐AuNSs is driven by the route of systemic delivery (intravenous vs...
As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show...
Polymer-coated gold nanoshells are assembled, using capillary forces, into packed clusters with tailored surface plasmon resonances. Separation between nanoshells is engineered to be ~2 nm. Strongly coupled resonances in nanoshell dimers and trimers are observed.
Surface-plasmon driven DNA dehybridization is a topic of intense current interest due to its highly promising potential for enabling light-controlled gene therapy: it is also of inherent interest as a light-driven nanoscale actuation process. In this study we formulate an Au nanoshell-based complex designed to release single-stranded DNA (ssDNA) from its surface when illuminated with plasmon-resonant...
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