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Two new glucuronide paclitaxel prodrugs have been synthesized. Linked to the 2′-OH of the drug by a carbonate function, they include a self-immolative spacer bearing an arylnitro or arylamino group between the drug and the glucuronic acid residue. Both prodrugs were well detoxified and easily cleaved in the presence of β-d-glucuronidase with fast removal of the spacer, releasing paclitaxel. The arylamino...
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