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An efficient synthesis of functionalized spirocyclic oximes from tricyclic heterocycles is reported. This novel method accomplishes high diastereoselectivity via an intramolecular 1,3-dipolar cycloaddition with a regenerating Michael linker strategy. Ring opening of the tricyclic N-(trimethylsilyloxy)pyrrolo[3,4-c]isoxazolidine framework was found to be essential for successful N-alkylation of the...
Peptide bond formation is catalyzed at the peptidyl transferase center (PTC) of the large ribosomal subunit. Crystal structures of the large ribosomal subunit of Haloarcula marismortui (Hma) complexed with several analogs that represent either the substrates or the transition state intermediate of the peptidyl transferase reaction show that this reaction proceeds through a tetrahedral intermediate...
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