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Second harmonic generation (SHG) has been used for the label-free detection of melittin upon intercalation into planar-supported lipid bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphotidylcholine (POPC). A novel counter-propagating SHG optical geometry was used to effectively isolate the achiral and chiral contributions of the surface, thus allowing for an investigation of both binding and structural...
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