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Brainamyloid composed of the ≈40-amino-acid human β-amyloid peptide Aβ is integral to Alzheimer's disease pathology. To probe the importance of a conformational transition in Aβ during amyloid growth, we synthesized and examined the solution conformation and amyloid deposition activity of Aβ congeners designed to have similar solution structures but to vary substantially in their barriers to conformational...
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