Search results for: Sharareh Emadi

Items from 1 to 14 out of 14 results

article

Enhancing anaerobic fermentation performance through eccentrically stirred mixing: Experimental and modeling methodology

Yuankai Huang, Farzaneh MahmoodPoor Dehkordy, Yan Li, Sharareh Emadi, more

Chemical Engineering Journal > 2018 > 334 > C > 1383-1391

Anaerobic hydrogen production (AHP) is a biochemical process capable of producing hydrogen and fatty acids from organic substrates in acidogenic phase. Currently, almost all of anaerobic systems use centrally stirred mixing where the flow is essentially rotated uniformly in the radial direction. Given the high energy requirement of mixing and the urgent needs for enhancing the contact between microbial...

article

Development of a self-assembling protein nanoparticle vaccine targeting Plasmodium falciparum Circumsporozoite Protein delivered in three Army Liposome Formulation adjuvants

Labdhi Seth, Karen M. Bingham Ferlez, Stephen A. Kaba, Derek M. Musser, more

Vaccine > 2017 > 35 > 41 > 5448-5454

We have developed FMP014, a vaccine candidate against Plasmodium falciparum malaria, which is comprised of 60 identical monomer protein chains that form an icosahedral shaped self-assembling protein nanoparticle (SAPN). Each monomer contains selected P. falciparum Circumsporozoite Protein (PfCSP) CD4+ and CD8+ epitopes, universal T_H epitopes, portions of the α-TSR domain, and 6 repeats of the NANP...

article

Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge

Christopher P. Karch, Jianping Li, Caroline Kulangara, Sara M. Paulillo, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2017 > 13 > 1 > 241-251

Current influenza vaccines should be improved by the addition of universal influenza vaccine antigens in order to protect against multiple virus strains. We used our self-assembling protein nanoparticles (SAPNs) to display the two conserved influenza antigens M2e and Helix C in their native oligomerization states. To further improve the immunogenicity of the SAPNs, we designed and incorporated the...

article

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Qiang Liu, Xitao Xie, Sharareh Emadi, Michael R. Sierks, more

Neuropharmacology > 2015 > 97 > Complete > 457-463

Loss of basal forebrain cholinergic neurons (BFCN) correlates with cognitive deficits in Alzheimer disease (AD). Our recent evidence suggests that chronic exposure to Aβ up-regulated neuronal α7-nAChRs and increased neuronal excitability in cultured hippocampal neurons. However, the impact of the up-regulated α7-nAChRs on Aβ-induced neurotoxicity remains unclear. In this study, we investigated the...

article

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Srinath Kasturirangan, Lin Li, Sharareh Emadi, Shanta Boddapati, more

Neurobiology of Aging > 2012 > 33 > 7 > 1320-1328

While accumulation and deposition of beta amyloid (Aβ) is a primary pathological feature of Alzheimer's disease (AD), increasing evidence has implicated small, soluble oligomeric aggregates of Aβ as the neurotoxic species in AD. Reagents that specifically recognize oligomeric morphologies of Aβ have potential diagnostic and therapeutic value. Using a novel biopanning technique that combines phage...

article

Characterizing Antibody Specificity to Different Protein Morphologies by AFM

Min S. Wang, Andleeb Zameer, Sharareh Emadi, Michael R. Sierks

Langmuir > 2009 > 25 > 2 > 912 - 918

article

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

Andleeb Zameer, Srinath Kasturirangan, Sharareh Emadi, Sridevi V. Nimmagadda, more

Journal of Molecular Biology > 2008 > 384 > 4 > 917-928

The Amyloid-β (Aβ) peptide is a major component of the amyloid plaques associated with Alzheimer's disease (AD). Recent studies suggest that the most toxic forms of Aβ are small, soluble oligomeric aggregates. Here, we report the isolation and characterization of a single-chain variable domain (scFv) antibody isolated against oligomeric Aβ using a protocol developed in our laboratory that combines...

article

Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy

Luda S. Shlyakhtenko, Bin Yuan, Sharareh Emadi, Yuri L. Lyubchenko, more

Nanomedicine: Nanotechnology, Biology, and Medicine > 2007 > 3 > 3 > 192-197

Protein misfolding and aggregation are a common thread in numerous diseases including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, diabetes, and prion-related diseases. Elucidation of the role played by the various protein forms in these diseases requires reagents that can target specific protein forms. Here we present a method to isolate antibodies that bind to a specific...

article

Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity

Sharareh Emadi, Hedieh Barkhordarian, Min S. Wang, Philip Schulz, more

Journal of Molecular Biology > 2007 > 368 > 4 > 1132-1144

Protein misfolding and aggregation are pathological aspects of numerous neurodegenerative diseases. Aggregates of α-synuclein are major components of the Lewy bodies and Lewy neurites associated with Parkinson's Disease (PD). A natively unfolded protein, α-synuclein can adopt different aggregated morphologies, including oligomers, protofibrils and fibrils. The small oligomeric aggregates have been...

article

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

Ruitian Liu, Hedieh Barkhordarian, Sharareh Emadi, Chan Beum Park, more

Neurobiology of Disease > 2005 > 20 > 1 > 74-81

A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Aβ) from its soluble monomeric form into various aggregated morphologies in the brain. Preventing aggregation of Aβ is being actively pursued as a primary therapeutic strategy for treating AD. Trehalose, a simple disaccharide, has been shown to be effective in preventing the deactivation of numerous...

article

A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein

Chun Zhou, Sharareh Emadi, Michael R. Sierks, Anne Messer

Molecular Therapy > 2004 > 10 > 6 > 1023-1031

α-Synuclein (α-syn) has been identified as the major component of Lewy bodies that characterize neurodegenerative synucleinopathies, including Parkinson's disease. Overexpression of α-syn, and prefibrillar α-syn oligomers, has been implicated in these pathologies; therefore, prevention of prefibril accumulation, and inhibition of other aberrant effects of overexpressed α-syn, could provide novel treatments...

article

Single Chain Variable Fragments against β-Amyloid (Aβ) Can Inhibit Aβ Aggregation and Prevent Aβ-Induced Neurotoxicity ^†

Ruitian Liu, Bin Yuan, Sharareh Emadi, Andleeb Zameer, more

Biochemistry > 2004 > 43 > 22 > 6959 - 6967

article

Inhibiting Aggregation of α-Synuclein with Human Single Chain Antibody Fragments ^†

Sharareh Emadi, Ruitian Liu, Bin Yuan, Philip Schulz, more

Biochemistry > 2004 > 43 > 10 > 2871 - 2878

article

Reversible inhibition by protamine of human synovial and rabbit platelet secretory phospholipase A ₂

Sharareh Emadi, Ismaïl Elalamy, B. Boris Vargaftig, Mohamed Hatmi

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism > 1996 > 1300 > 3 > 226-232

We investigated the effects of protamine on the release and the activity of 14 kDa type II phospholipase A ₂ (sPLA2). Protamine blocks both release and activity of sPLA2 from thrombin-stimulated platelets in a concentration-dependent manner. Heparin, an anionic sulfate polysaccharide which has a high affinity for this enzyme, has no inhibitory effect on sPLA2 by itself but it is able to...

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