Search results for: Fang-Hua Lee

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Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans

Hong Zhang, Hu Fu, Robert J. Luallen, Bingfen Liu, more

Vaccine > 2015 > 33 > 39 > 5140-5147

The glycan shield on the human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein has drawn attention as a target for HIV-1 vaccine design given that an increasing number of potent and broadly neutralizing antibodies (bNAbs) recognize epitopes entirely or partially comprised of high mannose type N-linked glycans. In an attempt to generate immunogens that target the glycan shield of HIV-1,...

article

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Lamorris M. Loftin, Martha F. Kienzle, Yanjie Yi, Benhur Lee, more

Virology > 2010 > 402 > 1 > 135-148

R5X4 HIV-1 has impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes. Greater lymphocyte CCR5 use correlated with relative resistance to CCR5 mAbs and small molecule antagonists. Increasing CCR5 expression on lymphocytes increased the proportion of entry...

article

Functional impact of HIV coreceptor-binding site mutations

Mark J. Biscone, John L. Miamidian, John M. Muchiri, Sarah S.W. Baik, more

Virology > 2006 > 351 > 1 > 226-236

The bridging sheet region of the gp120 subunit of the HIV-1 Env protein interacts with the major virus coreceptors, CCR5 and CXCR4. We examined the impact of mutations in and adjacent to the bridging sheet region of an X4 tropic HIV-1 on membrane fusion and entry inhibitor susceptibility. When the V3-loop of this Env was changed so that CCR5 was used, the effects of these same mutations on CCR5 use...

article

Receptor−Ligand Binding in the Cell−Substrate Contact Zone: A Quantitative Analysis Using CX3CR1 and CXCR1 Chemokine Receptors ^†

Fang-Hua Lee, Christopher Haskell, Isreal F. Charo, David Boettiger

Biochemistry > 2004 > 43 > 22 > 7179 - 7186

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Search results for: Fang-Hua Lee

Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Functional impact of HIV coreceptor-binding site mutations

Receptor−Ligand Binding in the Cell−Substrate Contact Zone: A Quantitative Analysis Using CX3CR1 and CXCR1 Chemokine Receptors ^†

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INFONA - science communication portal

Search results for: Fang-Hua Lee

Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Functional impact of HIV coreceptor-binding site mutations

Receptor−Ligand Binding in the Cell−Substrate Contact Zone: A Quantitative Analysis Using CX3CR1 and CXCR1 Chemokine Receptors †

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Receptor−Ligand Binding in the Cell−Substrate Contact Zone: A Quantitative Analysis Using CX3CR1 and CXCR1 Chemokine Receptors ^†