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We investigate the pressure‐induced structural changes in the mature human immunodeficiency virus type 1 protease dimer, using residual dipolar coupling (RDC) measurements in a weakly oriented solution. 1DNH RDCs were measured under high‐pressure conditions for an inhibitor‐free PR and an inhibitor‐bound complex, as well as for an inhibitor‐free multidrug resistant protease bearing 20 mutations (PR20)...
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