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The HIV-1 auxiliary protein Nef is required for the onset and progression of AIDS in HIV-1–infected persons. Here, we have deciphered the mode of action of a second-generation inhibitor of Nef, DLC27-14, presenting a competitive IC 50 of ∼16μM measured by MALDI-TOF experiments. Thermal protein denaturation experiments revealed a negative effect on stability of Nef in the presence of a saturating...
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