Search results for: Takao Yagi

Items from 1 to 20 out of 40 results

chapter

Genetic and Functional Analysis of Mitochondrial DNA-Encoded Complex I Genes

Yidong Bai, Peiqing Hu, Jeong Soon Park, Jian-Hong Deng, more

Annals of the New York Academy of Sciences > Mitochondrial Pathogenesis > 272-283

Mammalian mitochondrial NADH dehydrogenase (complex I) is a multimeric complex consisting of at least 45 subunits, 7 of which are encoded by mitochondrial DNA (mtDNA). The function of these subunits is largely unknown. We have established an efficient method to isolate and characterize cells carrying mutations in various mtDNA-encoded complex I genes. With this method, 15 mouse cell lines with deficiencies...

article

Long-term evaluation of Leber’s hereditary optic neuropathy-like symptoms in rotenone administered rats

Li Zhang, Laura Liu, Ann L. Philip, Juan C. Martinez, more

Neuroscience Letters > 2015 > 585 > Complete > 171-176

Leber’s hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer...

article

Essential regions in the membrane domain of bacterial complex I (NDH-1): the machinery for proton translocation

Motoaki Sato, Jesus Torres-Bacete, Prem Kumar Sinha, Akemi Matsuno-Yagi, more

Journal of Bioenergetics and Biomembranes > 2014 > 46 > 4 > 279-287

The proton-translocating NADH-quinone oxidoreductase (complex I/NDH-1) is the first and largest enzyme of the respiratory chain which has a central role in cellular energy production and is implicated in many human neurodegenerative diseases and aging. It is believed that the peripheral domain of complex I/NDH-1 transfers the electron from NADH to Quinone (Q) and the redox energy couples the proton...

article

Respiratory complex I: hop (structure), step (reaction mechanism) and jump (potential remedy)

Takao Yagi, Akemi Matsuno-Yagi

Journal of Bioenergetics and Biomembranes > 2014 > 46 > 4 > 245-246

article

Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier

Mathieu Marella, Gaurav Patki, Akemi Matsuno-Yagi, Takao Yagi

Neurobiology of Disease > 2013 > 58 > Complete > 281-288

Mitochondrial defects can have significant consequences on many aspects of neuronal physiology. In particular, deficiencies in the first enzyme complex of the mitochondrial respiratory chain (complex I) are considered to be involved in a number of human neurodegenerative diseases. The current work highlights a tight correlation between the inhibition of complex I and the state of axonal myelination...

article

Pivotal Roles of Three Conserved Carboxyl Residues of the NuoC (30k) Segment in the Structural Integrity of Proton-Translocating NADH-Quinone Oxidoreductase from Escherichia coli

Norma Castro-Guerrero, Prem Kumar Sinha, Jesus Torres-Bacete, Akemi Matsuno-Yagi, more

Biochemistry > 2010 > 49 > 47 > 10072 - 10080

article

Characterization of the Ubiquinone Binding Site in the Alternative NADH-Quinone Oxidoreductase of Saccharomyces cerevisiae by Photoaffinity Labeling

Masatoshi Murai, Tetsuo Yamashita, Mai Senoh, Yuko Mashimo, more

Biochemistry > 2010 > 49 > 13 > 2973 - 2980

article

The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor

Eiko Nakamaru-Ogiso, Hongna Han, Akemi Matsuno-Yagi, Ehud Keinan, more

FEBS Letters > 2010 > 584 > 5 > 883-888

NADH:ubiquinone oxidoreductase (complex I) is the entry enzyme of mitochondrial oxidative phosphorylation. To obtain the structural information on inhibitor/quinone binding sites, we synthesized [ ³ H]benzophenone-asimicin ([ ³ H]BPA), a photoaffinity analogue of asimicin, which belongs to the acetogenin family known as the most potent complex I inhibitor. We found that [ ³ ...

article

Effects of galantamine on l-NAME-induced behavioral impairment in Y-maze task in mice

Ken-ichi Tanaka, Takao Yagi, Ryosuke Shimakoshi, Koji Azuma, more

Neuroscience Letters > 2009 > 462 > 3 > 235-238

Nitric oxide (NO) may play a role in the established processes of learning and memory. We examined the effects of N^ω-nitro-l-arginine methylester (l-NAME), a nonselective inhibitor of NO synthase (NOS), on the performance of mice in a Y-maze task. l-NAME (100mg/kg) markedly impaired spontaneous alternation behavior. However, galantamine (0.5mg/kg) significantly attenuated this l-NAME-induced impairment...

article

Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy

Mathieu Marella, Byoung Boo Seo, Takao Yagi, Akemi Matsuno-Yagi

Journal of Bioenergetics and Biomembranes > 2009 > 41 > 6 > 493-497

Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson’s disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxygen species and a decreased energy supply. In the brain, the dopaminergic neurons...

article

Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) ^†

Naoya Ichimaru, Masatoshi Murai, Nobuyuki Kakutani, Junko Kako, more

Biochemistry > 2008 > 47 > 40 > 10816 - 10826

article

S4.27 Identification of the inhibitor binding SITE(S) in bovine complex-i by photoaffinity labeling

Masatoshi Murai, Naoya Ichimaru, Takao Yagi, Hideto Miyoshi

BBA - Bioenergetics > 2008 > 1777 > Supplement > S39

article

34 Lack of immune response associated with expression of the yeast Ndi1 enzyme in rodents

Byoung Boo Seo, Mathieu Marella, Akemi Matsuno-Yagi, Takao Yagi

Mitochondrion > 2007 > 7 > 6 > 413-414

article

78 Protection by the yeast Ndi1 enzyme against neurodegeneration in a chronic rat model of Parkinson’s disease

Mathieu Marella, Byoung Boo Seo, Eiko Nakamaru-Ogiso, Akemi Matsuno-Yagi, more

Mitochondrion > 2007 > 7 > 6 > 426-427

article

33 Protective role of NDI1 in a mouse Parkinson’s model

Jennifer Barber-Singh, Byoung Boo Seo, Akemi Matsuno-Yagi, Takao Yagi

Mitochondrion > 2007 > 7 > 6 > 413

article

The ND1 Subunit Constructs the Inhibitor Binding Domain in Bovine Heart Mitochondrial Complex I ^†

Masatoshi Murai, Atsushi Ishihara, Takaaki Nishioka, Takao Yagi, more

Biochemistry > 2007 > 46 > 21 > 6409 - 6416

article

The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I

Byoung Boo Seo, Mathieu Marella, Takao Yagi, Akemi Matsuno-Yagi

FEBS Letters > 2006 > 580 > 26 > 6105-6108

Using rat dopaminergic and human neuroblastoma cell lines transduced with the NDI1 gene encoding the internal NADH dehydrogenase (Ndi1) from Saccharomyces cerevisiae, we investigated reactive oxygen species (ROS) generation caused by complex I inhibition. Incubation of non-transduced cells with rotenone elicited oxidative damage to mitochondrial DNA as well as lipid peroxidation. In contrast, oxidative...

article

Total Synthesis of Piericidin A1 and B1 and Key Analogues

Martin J. Schnermann, F. Anthony Romero, Inkyu Hwang, Eiko Nakamaru-Ogiso, more

Journal of the American Chemical Society > 2006 > 128 > 36 > 11799 - 11807

article

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

Ranjita Betarbet, Rosa M. Canet-Aviles, Todd B. Sherer, Pier G. Mastroberardino, more

Neurobiology of Disease > 2006 > 22 > 2 > 404-420

Sporadic Parkinson's disease (PD) is most likely caused by a combination of environmental exposures and genetic susceptibilities, although there are rare monogenic forms of the disease. Mitochondrial impairment at complex I, oxidative stress, α-synuclein aggregation, and dysfunctional protein degradation, have been implicated in PD pathogenesis, but how they are related to each other is unclear. To...

article

Possibility of transkingdom gene therapy for Complex I diseases

Takao Yagi, Byoung Boo Seo, Eiko Nakamaru-Ogiso, Mathieu Marella, more

BBA - Bioenergetics > 2006 > 1757 > 5-6 > 708-714

Defects of complex I are involved in many human mitochondrial diseases, and therefore we have proposed to use the NDI1 gene encoding a single subunit NADH dehydrogenase of Saccharomyces cerevisiae for repair of respiratory activity. The yeast NDI1 gene was successfully introduced into mammalian cell lines. The expressed NDI1 protein was correctly targeted to the matrix side of the inner mitochondrial...

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Search results for: Takao Yagi

Genetic and Functional Analysis of Mitochondrial DNA-Encoded Complex I Genes

Long-term evaluation of Leber’s hereditary optic neuropathy-like symptoms in rotenone administered rats

Essential regions in the membrane domain of bacterial complex I (NDH-1): the machinery for proton translocation

Respiratory complex I: hop (structure), step (reaction mechanism) and jump (potential remedy)

Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier

Pivotal Roles of Three Conserved Carboxyl Residues of the NuoC (30k) Segment in the Structural Integrity of Proton-Translocating NADH-Quinone Oxidoreductase from Escherichia coli

Characterization of the Ubiquinone Binding Site in the Alternative NADH-Quinone Oxidoreductase of Saccharomyces cerevisiae by Photoaffinity Labeling

The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor

Effects of galantamine on l-NAME-induced behavioral impairment in Y-maze task in mice

Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy

Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) ^†

S4.27 Identification of the inhibitor binding SITE(S) in bovine complex-i by photoaffinity labeling

34 Lack of immune response associated with expression of the yeast Ndi1 enzyme in rodents

78 Protection by the yeast Ndi1 enzyme against neurodegeneration in a chronic rat model of Parkinson’s disease

33 Protective role of NDI1 in a mouse Parkinson’s model

The ND1 Subunit Constructs the Inhibitor Binding Domain in Bovine Heart Mitochondrial Complex I ^†

The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I

Total Synthesis of Piericidin A1 and B1 and Key Analogues

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

Possibility of transkingdom gene therapy for Complex I diseases

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