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We have refined the crystal structure of deoxyhemoglobin S (β Glu6 → Val) at 2.05 Å resolution to an R-factor of 16.5% (free R = 21.5%) using crystals isomorphous to those originally grown by Wishner and Love. A predominant feature of this crystal form is a double strand of hemoglobin tetramers that has been shown by a variety of techniques to be the fundamental building block of the intracellular...
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