Dorthe Aasland

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Repair gene O⁶‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation

Dorthe Aasland, Thomas R. Reich, Maja T. Tomicic, Olivier J. Switzeny, more

Journal of Neurochemistry > 144 > 2 > 139 - 151

Therapy of malignant glioma relies on treatment with the O⁶‐methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O⁶‐alkylguanine. Since this damage is repaired by O⁶‐methylguanine‐DNA methyltransferase (MGMT), the repair enzyme...

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The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

Karl-Heinz Tomaszowski, Dorthe Aasland, Geoffrey P. Margison, Emma Williams, more

DNA Repair > 2015 > 28 > Complete > 14-20

In both pro- and eukaryotes, the mutagenic and toxic DNA adduct O ⁶ -methylguanine (O ⁶ MeG) is subject to repair by alkyltransferase proteins via methyl group transfer. In addition, in prokaryotes, there are proteins with sequence homology to alkyltransferases, collectively designated as alkyltransferase-like (ATL) proteins, which bind to O ⁶ -alkylguanine adducts and mediate...

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Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs

Maja T. Tomicic, Dorthe Aasland, Teodora Nikolova, Bernd Kaina, more

BBA - Molecular Cell Research > 2013 > 1833 > 8 > 1832-1843

To counteract genotoxic stress, DNA repair functions are in effect. Most of them are constitutively expressed while some of them can be up-regulated depending on the level of DNA damage. In human cells, only few DNA repair functions are subject of induction following DNA damage, and thus there is a need to identify and characterize inducible repair functions more thoroughly. Here, we provide evidence...

article

c-Fos/AP-1 dependent regulation of the three prime exonuclease 1 (TREX1) by genotoxic stress

Markus Christmann, Maja Tomicic, Dorthe Aasland, Jana Schulz, more

Toxicology Letters > 2009 > 189 > Supplement > S129-S130

article

Analysis of the Leukemia Inhibitory Factor Receptor Functional Domains by Chimeric Receptors and Cytokines ^†

Dorthe Aasland, Björn Schuster, Joachim Grötzinger, Stefan Rose-John, more

Biochemistry > 2003 > 42 > 18 > 5244 - 5252

article

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex11Edited by M. Yaniv

Dorthe Aasland, Birgit Oppmann, Joachim Grötzinger, Stefan Rose-John, more

Journal of Molecular Biology > 2002 > 315 > 4 > 637-646

To elucidate the function of the two cytokine-binding modules (CBM) of the leukemia inhibitory factor receptor (LIFR), receptor chimeras of LIFR and the interleukin-6 receptor (IL-6R) were constructed. Either the NH₂-terminal (chimera RILLIFΔI) or the COOH-terminal LIFR CBM (chimera RILLIFΔII) were replaced by the structurally related CBM of the IL-6R which does not bind LIF. Chimera RILLIFΔI is functionally...

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Search results for: Dorthe Aasland

Repair gene O⁶‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs

c-Fos/AP-1 dependent regulation of the three prime exonuclease 1 (TREX1) by genotoxic stress

Analysis of the Leukemia Inhibitory Factor Receptor Functional Domains by Chimeric Receptors and Cytokines ^†

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex11Edited by M. Yaniv

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INFONA - science communication portal

Search results for: Dorthe Aasland

Repair gene O6‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs

c-Fos/AP-1 dependent regulation of the three prime exonuclease 1 (TREX1) by genotoxic stress

Analysis of the Leukemia Inhibitory Factor Receptor Functional Domains by Chimeric Receptors and Cytokines †

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex11Edited by M. Yaniv

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Repair gene O⁶‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation

Analysis of the Leukemia Inhibitory Factor Receptor Functional Domains by Chimeric Receptors and Cytokines ^†